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Molecular Therapy. Nucleic Acids|May 20, 2022
Subcutaneous delivery of FGF21 mRNA therapy reverses obesity, insulin resistance, and hepatic steatosis in diet-induced obese miceStefano Bartesaghi, Kristina Wallenius, Daniel Hovdal, et al.The Journal of Pharmacology and Experimental Therapeutics|September 28, 2025
Preclinical evaluation and first-in-human phase 1 trial of AZD0186, a novel, oral small molecule glucagon-like peptide-1 receptor agonistWeier Qi, Simina M Boca, Alessandro Boianelli, et al.Diabetes, Obesity & Metabolism|November 4, 2024
Non-clinical and first-in-human characterization of ECC5004/AZD5004, a novel once-daily, oral small-molecule GLP-1 receptor agonistAmina Z Haggag, Jianfeng Xu, Laurie Butcher, et al.JCI Insight|October 17, 2024
Knockdown of ketohexokinase versus inhibition of its kinase activity exert divergent effects on fructose metabolismSe-Hyung Park, Taghreed Fadhul, Lindsey R Conroy, et al.Elife|January 17, 2023
FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitisCong Liu, Milena Schönke, Borah Spoorenberg, et al.Pageof 3