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ACS Medicinal Chemistry Letters|September 24, 2015
Fragment-Based Drug Design of Novel Pyranopyridones as Cell Active and Orally Bioavailable Tankyrase InhibitorsJavier de Vicente, Parcharee Tivitmahaisoon, Pamela Berry, et al.ACS Medicinal Chemistry Letters|January 15, 2025
Discovery of Rezatapopt (PC14586), a First-in-Class, Small-Molecule Reactivator of p53 Y220C Mutant in DevelopmentBinh T Vu, Romyr Dominique, Bruce J Fahr, et al.The Biochemical Journal|December 3, 2011
Allosteric antibody inhibition of human hepsin proteaseTobias Koschubs, Stefan Dengl, Harald Dürr, et al.Journal of Medicinal Chemistry|April 10, 2014
Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β agonist in clinical trials for the treatment of dyslipidemiaMartha J Kelly, Sherrie Pietranico-Cole, J Douglas Larigan, et al.Cancer Research|February 19, 2008
A selective phosphatase of regenerating liver phosphatase inhibitor suppresses tumor cell anchorage-independent growth by a novel mechanism involving p130Cas cleavageSherif Daouti, Wen-hui Li, Hong Qian, et al.Journal of Medicinal Chemistry|March 19, 2011
Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetesYimin Qian, Stanley J Wertheimer, Mushtaq Ahmad, et al.Science Advances|May 23, 2020
Inhibition of IRF5 cellular activity with cell-penetrating peptides that target homodimerizationJaspreet Banga, Dinesh Srinivasan, Chia-Chi Sun, et al.Science Translational Medicine|March 8, 2023
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug targetEva S Istvan, Francisco Guerra, Matthew Abraham, et al.Cancer Discovery|February 13, 2025
Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule ReactivatorAnna M Puzio-Kuter, Lizhong Xu, Mary Kate McBrayer, et al.Pageof 2