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Journal of Pharmaceutical and Biomedical Analysis|June 13, 2012
Early rapid identification of in vivo rat metabolites of AN6414, a novel boron-containing PDE4 inhibitor by QTRAP LC/MS/MS to support drug discoveryWei Bu, Tsutomu Akama, Sanjay Chanda, et al.
Genome Research|May 4, 2005
Classification of a large microarray data set: algorithm comparison and analysis of drug signaturesGeorges Natsoulis, Laurent El Ghaoui, Gert R G Lanckriet, et al.
The Journal of Pharmacology and Experimental Therapeutics|September 20, 2013
Linking phenotype to kinase: identification of a novel benzoxaborole hinge-binding motif for kinase inhibition and development of high-potency rho kinase inhibitorsTsutomu Akama, Chen Dong, Charlotte Virtucio, et al.
The Journal of Pharmacology and Experimental Therapeutics|November 30, 2012
Inhibition of Toll-like receptor-mediated inflammation in vitro and in vivo by a novel benzoxaboroleChen Dong, Holly Sexton, Ana Gertrudes, et al.
Molecular Systems Biology|March 28, 2008
The liver pharmacological and xenobiotic gene response repertoireGeorges Natsoulis, Cecelia I Pearson, Jeremy Gollub, et al.
The Journal of Pharmacology and Experimental Therapeutics|June 30, 2016
Treatment of Skin Inflammation with Benzoxaborole Phosphodiesterase Inhibitors: Selectivity, Cellular Activity, and Effect on Cytokines Associated with Skin Inflammation and Skin Architecture ChangesChen Dong, Charlotte Virtucio, Olga Zemska, et al.
Bioorganic & Medicinal Chemistry Letters|October 1, 2013
Discovery and structure-activity relationships of 6-(benzoylamino)benzoxaboroles as orally active anti-inflammatory agentsTsutomu Akama, Chen Dong, Charlotte Virtucio, et al.
FEBS Letters|July 31, 2012
Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal centerYvonne R Freund, Tsutomu Akama, M R K Alley, et al.
Bioorganic & Medicinal Chemistry Letters|February 16, 2013
Structure-activity relationships of 6-(aminomethylphenoxy)-benzoxaborole derivatives as anti-inflammatory agentTsutomu Akama, Charlotte Virtucio, Chen Dong, et al.
Plos Neglected Tropical Diseases|July 14, 2017
Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug targetThavy Long, Liliana Rojo-Arreola, Da Shi, et al.
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