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Journal of Medicinal Chemistry|March 27, 2024
Discovery of a Potent, Selective, and Cell-Active SPIN1 InhibitorYan Xiong, Holger Greschik, Catrine Johansson, et al.Cell Chemical Biology|September 1, 2021
A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cellsChenxi Xu, Fanye Meng, Kwang-Su Park, et al.Science Translational Medicine|September 29, 2021
A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse modelsXufen Yu, Dongxu Li, Jithesh Kottur, et al.Journal of Medicinal Chemistry|July 2, 2019
Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1)Yan Xiong, Holger Greschik, Catrine Johansson, et al.Nature Communications|May 6, 2025
Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer's disease-associated proteopathologyLing Xie, Ryan N Sheehy, Adil Muneer, et al.Journal of Medicinal Chemistry|February 16, 2021
A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6Yudao Shen, Fengling Li, Magdalena M Szewczyk, et al.Pageof 6