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ACS Medicinal Chemistry Letters|June 6, 2014
Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA InhibitorsTao Wang, Michelle L Lamb, Michael H Block, et al.Journal of Medicinal Chemistry|December 9, 2010
Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathwayStephanos Ioannidis, Michelle L Lamb, Tao Wang, et al.Bioorganic & Medicinal Chemistry Letters|March 22, 2018
Discovery of 2,6-disubstituted pyrazine derivatives as inhibitors of CK2 and PIM kinasesLakshmaiah Gingipalli, Michael H Block, Larry Bao, et al.ACS Chemical Biology|December 27, 2021
Mechanistic Insights into a CDK9 Inhibitor Via Orthogonal Proteomics MethodsJ Adam Hendricks, Nigel Beaton, Alexey Chernobrovkin, et al.Blood|December 24, 2013
AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemiaErika K Keeton, Kristen McEachern, Keith S Dillman, et al.Journal of Medicinal Chemistry|July 24, 2008
Identification of 4-aminopyrazolylpyrimidines as potent inhibitors of Trk kinasesTao Wang, Michelle L Lamb, David A Scott, et al.Cancer Research|October 10, 2018
Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast CancerZebin Wang, Shaun E Grosskurth, Tony Cheung, et al.Bioorganic & Medicinal Chemistry Letters|November 8, 2015
Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clusteringJeffrey W Johannes, Lynsie Almeida, Kevin Daly, et al.Chemmedchem|December 22, 2017
Structure-Based Design of Selective Noncovalent CDK12 InhibitorsJeffrey W Johannes, Christopher R Denz, Nancy Su, et al.Journal of Medicinal Chemistry|June 25, 2024
Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1Simon C C Lucas, Alexander G Milbradt, J Henry Blackwell, et al.Pageof 28