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ACS Medicinal Chemistry Letters|July 16, 2021
Balancing Properties with Carboxylates: A Lead Optimization Campaign for Selective and Orally Active CDK9 InhibitorsYunsong Tong, Alan S Florjancic, Rick F Clark, et al.
Journal of Medicinal Chemistry|July 9, 2025
Discovery of Orally Efficacious Bridged Piperazines as smTNF ModulatorsZhiguo Bian, Robert G Schmidt, Noel S Wilson, et al.
ACS Chemical Biology|February 21, 2022
The HPK1 Inhibitor A-745 Verifies the Potential of Modulating T Cell Kinase Signaling for ImmunotherapySven Malchow, Alla Korepanova, Sanjay C Panchal, et al.
Bioorganic & Medicinal Chemistry Letters|May 14, 2013
Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: synthesis and characterization of analogs with a fused 5,6-bicyclic ring motifA Chris Krueger, John T Randolph, David A DeGoey, et al.
Journal of Medicinal Chemistry|January 18, 2018
Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral BioavailabilityJohn T Randolph, A Chris Krueger, Pamela L Donner, et al.
Journal of Medicinal Chemistry|December 30, 2020
Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug DesignJustin D Dietrich, Kenton L Longenecker, Noel S Wilson, et al.
Science Translational Medicine|March 20, 2024
An anti-TNF-glucocorticoid receptor modulator antibody-drug conjugate is efficacious against immune-mediated inflammatory diseasesMichael J McPherson, Adrian D Hobson, Axel Hernandez, et al.
Journal of Medicinal Chemistry|October 13, 2006
Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetesDavid J Madar, Hana Kopecka, Daisy Pireh, et al.
Molecular Cancer Therapeutics|May 5, 2017
Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT InhibitorsJulie L Wilsbacher, Min Cheng, Dong Cheng, et al.
Bioorganic & Medicinal Chemistry Letters|June 15, 2017
SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT)Michael L Curtin, H Robin Heyman, Richard F Clark, et al.
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