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Bioorganic & Medicinal Chemistry Letters|January 4, 2011
Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probePaul R Reid, Thomas M Bridges, Douglas J Sheffler, et al.
Molecular Pharmacology|May 2, 2009
A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learningDouglas J Sheffler, Richard Williams, Thomas M Bridges, et al.
ACS Chemical Neuroscience|October 1, 2011
Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous systemEvan P Lebois, Thomas M Bridges, L Michelle Lewis, et al.
Current Topics in Medicinal Chemistry|October 8, 2009
Discovery and development of a potent and highly selective small molecule muscarinic acetylcholine receptor subtype I (mAChR 1 or M1) antagonist in vitro and in vivo probeC David Weaver, Douglas J Sheffler, L Michelle Lewis, et al.
The Journal of Biological Chemistry|October 4, 2012
Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmiasFranck Potet, Amanda N Lorinc, Sebastien Chaigne, et al.
ACS Chemical Neuroscience|September 17, 2014
Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7Nidhi Jalan-Sakrikar, Julie R Field, Rebecca Klar, et al.
ACS Chemical Neuroscience|February 28, 2012
The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's DiseaseZixiu Xiang, Analisa D Thompson, John T Brogan, et al.
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