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L P Wakelin

Showing results (51-60 of 66) with videos related to

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Journal of Medicinal Chemistry|January 1, 1991
Synthesis and evaluation of DNA-targeted spatially separated bis(aniline mustards) as potential alkylating agents with enhanced DNA cross-linking capabilityT A Gourdie, A S Prakash, L P Wakelin, et al.
Anti-Cancer Drug Design|July 1, 1991
Synthesis and anti-tumour activity of the spatially-separated mustard bis-N,N'-[3-(N-(2-chloroethyl)-N-ethyl)amino-5-[N,N-dimethylamino)methy l)-aminophenyl]-1,4-benzenedicarboxamide, which alkylates DNA exclusively at adenines in the minor grooveA S Prakash, K K Valu, L P Wakelin, et al.
Biochemistry|November 14, 1978
Structural limitations on the bifunctional intercalation of diacridines into DNAL P Wakelin, M Romanos, T K Chen, et al.
Molecular Pharmacology|August 23, 2000
Acridinecarboxamide topoisomerase poisons: structural and kinetic studies of the DNA complexes of 5-substituted 9-amino-(N-(2-dimethylamino)ethyl)acridine-4-carboxamidesA Adams, J M Guss, C A Collyer, et al.
Journal of Medicinal Chemistry|March 3, 1999
Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5-BrU)ACG)2 at 1.3-A resolutionA K Todd, A Adams, J H Thorpe, et al.
Biochemistry|October 23, 1990
DNA-directed alkylating ligands as potential antitumor agents: sequence specificity of alkylation by intercalating aniline mustardsA S Prakash, W A Denny, T A Gourdie, et al.
Journal of Medicinal Chemistry|November 1, 1982
N-Methylnalorphine: definition of N-allyl conformation for antagonism at the opiate receptorR J Kobylecki, A C Lane, C F Smith, et al.
Anti-Cancer Drug Design|October 1, 1992
Synthesis, DNA binding interactions and biological activity of bis platinum (II) complexes of N,N,N',N'-tetrakis(2-aminoethyl)diaminesB D Palmer, G Wickham, D J Craik, et al.
Journal of Medicinal Chemistry|November 1, 1990
DNA-directed alkylating agents. 2. Synthesis and biological activity of platinum complexes linked to 9-anilinoacridineB D Palmer, H H Lee, P Johnson, et al.
Anti-Cancer Drug Design|November 10, 1998
Synthesis of new bifunctional compounds which selectively alkylate guanines in DNAN D Henderson, S M Lacy, C C O'Hare, et al.
Pageof 7

Showing results (51-60 of 66) with videos related to

Sort By:
Pageof 7
Journal of Medicinal Chemistry|January 1, 1991
Synthesis and evaluation of DNA-targeted spatially separated bis(aniline mustards) as potential alkylating agents with enhanced DNA cross-linking capabilityT A Gourdie, A S Prakash, L P Wakelin, et al.
Anti-Cancer Drug Design|July 1, 1991
Synthesis and anti-tumour activity of the spatially-separated mustard bis-N,N'-[3-(N-(2-chloroethyl)-N-ethyl)amino-5-[N,N-dimethylamino)methy l)-aminophenyl]-1,4-benzenedicarboxamide, which alkylates DNA exclusively at adenines in the minor grooveA S Prakash, K K Valu, L P Wakelin, et al.
Biochemistry|November 14, 1978
Structural limitations on the bifunctional intercalation of diacridines into DNAL P Wakelin, M Romanos, T K Chen, et al.
Molecular Pharmacology|August 23, 2000
Acridinecarboxamide topoisomerase poisons: structural and kinetic studies of the DNA complexes of 5-substituted 9-amino-(N-(2-dimethylamino)ethyl)acridine-4-carboxamidesA Adams, J M Guss, C A Collyer, et al.
Journal of Medicinal Chemistry|March 3, 1999
Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5-BrU)ACG)2 at 1.3-A resolutionA K Todd, A Adams, J H Thorpe, et al.
Biochemistry|October 23, 1990
DNA-directed alkylating ligands as potential antitumor agents: sequence specificity of alkylation by intercalating aniline mustardsA S Prakash, W A Denny, T A Gourdie, et al.
Journal of Medicinal Chemistry|November 1, 1982
N-Methylnalorphine: definition of N-allyl conformation for antagonism at the opiate receptorR J Kobylecki, A C Lane, C F Smith, et al.
Anti-Cancer Drug Design|October 1, 1992
Synthesis, DNA binding interactions and biological activity of bis platinum (II) complexes of N,N,N',N'-tetrakis(2-aminoethyl)diaminesB D Palmer, G Wickham, D J Craik, et al.
Journal of Medicinal Chemistry|November 1, 1990
DNA-directed alkylating agents. 2. Synthesis and biological activity of platinum complexes linked to 9-anilinoacridineB D Palmer, H H Lee, P Johnson, et al.
Anti-Cancer Drug Design|November 10, 1998
Synthesis of new bifunctional compounds which selectively alkylate guanines in DNAN D Henderson, S M Lacy, C C O'Hare, et al.
Pageof 7