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Cancer Discovery|December 18, 2012
The mTORC1 inhibitor everolimus prevents and treats Eμ-Myc lymphoma by restoring oncogene-induced senescenceMeaghan Wall, Gretchen Poortinga, Kym L Stanley, et al.
Science Signaling|September 1, 2011
AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancerJoanna C Chan, Katherine M Hannan, Kim Riddell, et al.
Oncotarget|July 9, 2016
Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signalingJaclyn Quin, Keefe T Chan, Jennifer R Devlin, et al.
European Journal of Cancer (Oxford, England : 1990)|September 10, 2013
Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitorsKaren E Sheppard, Carleen Cullinane, Katherine M Hannan, et al.
The Journal of Clinical Investigation|January 5, 2012
An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in miceKathryn M Kinross, Karen G Montgomery, Margarete Kleinschmidt, et al.
Cancer Cell|July 14, 2012
Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53Megan J Bywater, Gretchen Poortinga, Elaine Sanij, et al.
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