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Cancer Research Communications|July 19, 2024
BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian CancerHussein Chehade, Radhika Gogoi, Nicholas K Adzibolosu, et al.Journal of Medicinal Chemistry|September 2, 2011
Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferaseLei Wang, Sita Kugel Desmoulin, Christina Cherian, et al.Biochemistry|February 7, 2024
Structural Characterization of 5-Substituted Pyrrolo[3,2-d]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2Jade M Katinas, Md Junayed Nayeen, Mathew Schneider, et al.Blood|October 27, 2005
Differential gene expression, GATA1 target genes, and the chemotherapy sensitivity of Down syndrome megakaryocytic leukemiaYubin Ge, Alan A Dombkowski, Katherine M LaFiura, et al.Scientific Reports|July 5, 2022
Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironmentAdrianne Wallace-Povirk, Lisa Rubinsak, Agnes Malysa, et al.ACS Pharmacology & Translational Science|May 18, 2023
Multitargeted 6-Substituted Thieno[2,3-d]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon MetabolismNian Tong, Jennifer Wong-Roushar, Adrianne Wallace-Povirk, et al.Cancer|February 11, 2004
Reduced folate carrier mutations are not the mechanism underlying methotrexate resistance in childhood acute lymphoblastic leukemiaYotam Kaufman, Stavit Drori, Peter D Cole, et al.Journal of Medicinal Chemistry|August 29, 2015
6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human TumorsLei Wang, Adrianne Wallace, Sudhir Raghavan, et al.Molecular Cancer Therapeutics|February 20, 2024
Mitochondrial and Cytosolic One-Carbon Metabolism Is a Targetable Metabolic Vulnerability in Cisplatin-Resistant Ovarian CancerAdrianne Wallace-Povirk, Carrie O'Connor, Aamod S Dekhne, et al.Journal of Medicinal Chemistry|July 27, 2016
Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide BiosynthesisLalit K Golani, Adrianne Wallace-Povirk, Siobhan M Deis, et al.Pageof 13