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Journal of Medicinal Chemistry|September 20, 2014
Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptors α and β and the proton-coupled folate transporterLalit K Golani, Christina George, Sai Zhao, et al.Journal of Medicinal Chemistry|November 22, 2013
Discovery of 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as dual-acting inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis: implications of inhibiting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase to ampk activation and antitumor activityShermaine Mitchell-Ryan, Yiqiang Wang, Sudhir Raghavan, et al.Blood|July 30, 2009
RUNX1 regulates phosphoinositide 3-kinase/AKT pathway: role in chemotherapy sensitivity in acute megakaryocytic leukemiaHolly Edwards, Chengzhi Xie, Katherine M LaFiura, et al.Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|January 24, 2006
Transcriptional regulation of the human reduced folate carrier in childhood acute lymphoblastic leukemia cellsMingjun Liu, Yubin Ge, Scott G Payton, et al.Journal of the National Cancer Institute|February 3, 2005
GATA1, cytidine deaminase, and the high cure rate of Down syndrome children with acute megakaryocytic leukemiaYubin Ge, Mark L Stout, Dana A Tatman, et al.Journal of Medicinal Chemistry|January 21, 2010
Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entryLei Wang, Christina Cherian, Sita Kugel Desmoulin, et al.Molecular Pharmacology|September 24, 2011
Therapeutic targeting of a novel 6-substituted pyrrolo [2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporterSita Kugel Desmoulin, Lei Wang, Eric Hales, et al.American Journal of Physiology. Cell Physiology|September 28, 2007
Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restrictionAndong Qiu, Sang Hee Min, Michaela Jansen, et al.Tumori|March 10, 2010
DNA/RNA markers for colorectal cancer risk in preserved stool specimens: a pilot studyIkuko Kato, Kawsar Z Badsha, Susan Land, et al.International Journal of Molecular Sciences|April 17, 2020
RX-3117 (Fluorocyclopentenyl-Cytosine)-Mediated Down-Regulation of DNA Methyltransferase 1 Leads to Protein Expression of Tumor-Suppressor Genes and Increased Functionality of the Proton-Coupled Folate CarrierDzjemma Sarkisjan, Joris R Julsing, Btissame El Hassouni, et al.Pageof 13