Showing results (1-10 of 11) with videos related to

Sort By:
Pageof 2
Frontiers in Aging Neuroscience|June 27, 2022
PINK1/Parkin Pathway Activation for Mitochondrial Quality Control - Which Is the Best Molecular Target for Therapy?Laura F Silvian
BMC Structural Biology|June 2, 2016
Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligandDouglas J Marcotte, YuTing Liu, Kevin Little, et al.
Plos One|November 11, 2016
ATP-Competitive MLKL Binders Have No Functional Impact on NecroptosisBin Ma, Doug Marcotte, Murugan Paramasivam, et al.
Protein Science : a Publication of the Protein Society|December 28, 2017
Lock and chop: A novel method for the generation of a PICK1 PDZ domain and piperidine-based inhibitor co-crystal structureDouglas J Marcotte, Jean-Christophe Hus, Charles C Banos, et al.
Iscience|January 13, 2022
Discovery of small-molecule positive allosteric modulators of Parkin E3 ligaseEvgeny Shlevkov, Paramasivam Murugan, Dan Montagna, et al.
ACS Chemical Biology|March 23, 2011
Small molecule inhibition of the TNF family cytokine CD40 ligand through a subunit fracture mechanismLaura F Silvian, Jessica E Friedman, Kathy Strauch, et al.
Nature Communications|September 19, 2024
Activation of parkin by a molecular glueVéronique Sauvé, Eric Stefan, Nathalie Croteau, et al.
Protein Science : a Publication of the Protein Society|January 7, 2010
Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinasesDouglas J Marcotte, Yu-Ting Liu, Robert M Arduini, et al.
Protein Science : a Publication of the Protein Society|October 12, 2016
Germinal-center kinase-like kinase co-crystal structure reveals a swapped activation loop and C-terminal extensionDouglas Marcotte, Mia Rushe, Robert M Arduini, et al.
Bioorganic & Medicinal Chemistry Letters|December 20, 2022
Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse modelGeorge H Vandeveer, Robert M Arduini, Darren P Baker, et al.
Pageof 2