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European Journal of Medicinal Chemistry|April 24, 2026
Discovery of APO-50815, a potent WEE1 kinase inhibitor with exceptional efficacy against patient-derived colorectal cancer organoidsJoel L Syphers, Josephine A Wright, Rebekah de Nys, et al.Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|May 8, 2020
Medium-throughput Drug Screening of Patient-derived Organoids from Colorectal Peritoneal Metastases to Direct Personalized TherapyVignesh Narasimhan, Josephine A Wright, Michael Churchill, et al.Gut|April 19, 2018
Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesisTamsin R M Lannagan, Young K Lee, Tongtong Wang, et al.Biorxiv : the Preprint Server for Biology|April 17, 2023
Colorectal cancer detection and treatment with engineered probioticsCandice R Gurbatri, Georgette Radford, Laura Vrbanac, et al.Journal of Medicinal Chemistry|April 10, 2025
Discovery of WEE1 Kinase Inhibitors with Potent Activity against Patient-Derived, Metastatic Colorectal Cancer OrganoidsJoel L Syphers, Josephine A Wright, Shen Liu, et al.Nature Communications|January 20, 2024
Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasiaCandice R Gurbatri, Georgette A Radford, Laura Vrbanac, et al.Gastroenterology|November 16, 2020
The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal CarcinogenesisHiroki Kobayashi, Krystyna A Gieniec, Josephine A Wright, et al.Gastroenterology|December 9, 2021
The Origin and Contribution of Cancer-Associated Fibroblasts in Colorectal CarcinogenesisHiroki Kobayashi, Krystyna A Gieniec, Tamsin R M Lannagan, et al.Pageof 2