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Nature Communications|January 18, 2025
The clinical-stage drug BTZ-043 accumulates in murine tuberculosis lesions and efficiently acts against Mycobacterium tuberculosisAndreas Römpp, Axel Treu, Julia Kokesch-Himmelreich, et al.Ebiomedicine|January 3, 2025
Experimental medicine study with stabilised native-like HIV-1 Env immunogens drives long-term antibody responses, but lacks neutralising breadthKatrina M Pollock, Hannah M Cheeseman, Leon R McFarlane, et al.British Journal of Clinical Pharmacology|November 28, 2022
The effect of TRV027 on coagulation in COVID-19: A pilot randomized, placebo-controlled trialAlexander J Robbins, Nur Amalina Che Bakri, Edward Toke-Bjolgerud, et al.Bioorganic & Medicinal Chemistry Letters|September 11, 2012
HCV NS5A replication complex inhibitors. Part 2: investigation of stilbene prolinamidesDenis R St Laurent, Makonen Belema, Min Gao, et al.Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|December 14, 2019
Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B CellsElizabeth A Lemm, Beatriz Valle-Argos, Lindsay D Smith, et al.Journal of Medicinal Chemistry|January 21, 2014
Hepatitis C virus NS5A replication complex inhibitors. Part 6: Discovery of a novel and highly potent biarylimidazole chemotype with inhibitory activity toward genotypes 1a and 1b repliconsMakonen Belema, Van N Nguyen, Jeffrey L Romine, et al.Nature|November 5, 2015
Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5AJin-Hua Sun, Donald R O'Boyle, Robert A Fridell, et al.Bioorganic & Medicinal Chemistry Letters|June 22, 2017
Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymeraseBarbara Zhizhen Zheng, Stanley V D'Andrea, Umesh Hanumegowda, et al.Bioorganic & Medicinal Chemistry Letters|January 1, 2013
HCV NS5A replication complex inhibitors. Part 3: discovery of potent analogs with distinct core topologiesOmar D Lopez, Van N Nguyen, Denis R St Laurent, et al.ACS Medicinal Chemistry Letters|July 26, 2017
Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase InhibitorKyle Parcella, Kyle Eastman, Kap-Sun Yeung, et al.Pageof 29