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Journal of Pharmaceutical Sciences|October 20, 2006
On the calculation of the concentration dependence of drug binding to plasma proteins with multiple binding sites of different affinities: determination of the possible variation of the unbound drug fraction and calculation of the number of binding sites of the proteinLeonid M BerezhkovskiyJournal of Pharmaceutical Sciences|May 5, 2004
Volume of distribution at steady state for a linear pharmacokinetic system with peripheral eliminationLeonid M BerezhkovskiyJournal of Pharmaceutical Sciences|February 21, 2006
A convenient method for estimating the quantity of drug eliminated by the routes other than hepatic metabolism and renal excretion and the fraction of drug that reaches the "first pass" after oral administrationLeonid M BerezhkovskiyJournal of Pharmaceutical Sciences|September 11, 2007
Prediction of the possibility of the second peak of drug plasma concentration time curve after iv bolus administration from the standpoint of the traditional multi-compartmental linear pharmacokineticsLeonid M BerezhkovskiyJournal of Pharmaceutical Sciences|May 29, 2008
Determination of mean residence time of drug in plasma and the influence of the initial drug elimination and distribution on the calculation of pharmacokinetic parametersLeonid M BerezhkovskiyJournal of Pharmaceutical Sciences|February 15, 2012
On the accuracy of determination of unbound drug fraction in tissue using diluted tissue homogenateLeonid M BerezhkovskiyJournal of Pharmaceutical Sciences|October 15, 2009
On the influence of protein binding on pharmacological activity of drugsLeonid M BerezhkovskiyJournal of Pharmacokinetics and Pharmacodynamics|July 15, 2006
Determination of drug binding to plasma proteins using competitive equilibrium binding to dextran-coated charcoalLeonid M BerezhkovskiyXenobiotica; the Fate of Foreign Compounds in Biological Systems|September 26, 2015
On the accuracy of calculation of the mean residence time of drug in the body and its volumes of distribution based on the assumption of central eliminationLeonid M BerezhkovskiyJournal of Pharmaceutical Sciences|September 25, 2012
Conceptual underestimation of the total body clearance by the sum of clearances of individual organs in physiologically based pharmacokineticsLeonid M BerezhkovskiyPageof 4