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Journal of Pharmaceutical Sciences|January 22, 2011
On the accuracy of estimation of basic pharmacokinetic parameters by the traditional noncompartmental equations and the prediction of the steady-state volume of distribution in obese patients based upon data derived from normal subjectsLeonid M BerezhkovskiyJournal of Pharmaceutical Sciences|March 1, 2011
The corrected traditional equations for calculation of hepatic clearance that account for the difference in drug ionization in extracellular and intracellular tissue water and the corresponding corrected PBPK equationLeonid M BerezhkovskiyJournal of Pharmaceutical Sciences|June 13, 2016
Exploration of PBPK Model-Calculation of Drug Time Course in Tissue Using IV Bolus Drug Plasma Concentration-Time Profile and the Physiological Parameters of the OrganLeonid M BerezhkovskiyJournal of Pharmaceutical Sciences|July 14, 2007
On the determination of the time delay in reaching the steady state drug concentration in the organ compared to plasmaLeonid M BerezhkovskiyJournal of Pharmaceutical Sciences|April 3, 2009
Prediction of the possibility of the secondary peaks of iv bolus drug plasma concentration time curve by the model that directly takes into account the transit time through the organLeonid M BerezhkovskiyJournal of Pharmaceutical Sciences|August 16, 2008
Consideration of the linear concentration increase of the unbound drug fraction in plasmaLeonid M BerezhkovskiyJournal of Pharmaceutical Sciences|July 19, 2011
The influence of hepatic transport on the distribution volumes and mean residence time of drug in the body and the accuracy of estimating these parameters by the traditional pharmacokinetic calculationsLeonid M BerezhkovskiyJournal of Pharmaceutical Sciences|July 7, 2012
Determination of hepatic clearance with the account of drug-protein binding kineticsLeonid M BerezhkovskiyJournal of Pharmaceutical Sciences|January 6, 2004
Determination of volume of distribution at steady state with complete consideration of the kinetics of protein and tissue binding in linear pharmacokineticsLeonid M BerezhkovskiyJournal of Pharmaceutical Sciences|February 24, 2006
The influence of drug kinetics in blood on the calculation of oral bioavailability in linear pharmacokinetics: the traditional equation may considerably overestimate the true valueLeonid M BerezhkovskiyPageof 4