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Investigational New Drugs|November 18, 2017
ATP-binding cassette transporters limit the brain penetration of Wee1 inhibitorsMark C de Gooijer, Levi C M Buil, Jos H Beijnen, et al.
International Journal of Cancer|September 19, 2017
The impact of P-glycoprotein and breast cancer resistance protein on the brain pharmacokinetics and pharmacodynamics of a panel of MEK inhibitorsMark C de Gooijer, Ping Zhang, Ruud Weijer, et al.
International Journal of Cancer|April 15, 2015
ABCB1 and ABCG2 restrict the brain penetration of a panel of novel EZH2-InhibitorsPing Zhang, Mark C de Gooijer, Levi C M Buil, et al.
Molecular Pharmaceutics|September 26, 2018
ABCB1 Attenuates the Brain Penetration of the PARP Inhibitor AZD2461Mark C de Gooijer, Levi C M Buil, Ceren H Çitirikkaya, et al.
Investigational New Drugs|July 1, 2015
P-glycoprotein and breast cancer resistance protein restrict the brain penetration of the CDK4/6 inhibitor palbociclibMark C de Gooijer, Ping Zhang, Nishita Thota, et al.
Scientific Reports|July 19, 2018
Buparlisib is a brain penetrable pan-PI3K inhibitorMark C de Gooijer, Ping Zhang, Levi C M Buil, et al.
Neoplasia (New York, N.Y.)|June 1, 2018
Improved Brain Penetration and Antitumor Efficacy of Temozolomide by Inhibition of ABCB1 and ABCG2Mark C de Gooijer, Nienke A de Vries, Tessa Buckle, et al.
Cell Reports. Medicine|February 1, 2021
ATP-binding cassette transporters restrict drug delivery and efficacy against brain tumors even when blood-brain barrier integrity is lostMark C de Gooijer, E Marleen Kemper, Levi C M Buil, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|March 21, 2014
ABCB1, ABCG2, and PTEN determine the response of glioblastoma to temozolomide and ABT-888 therapyFan Lin, Mark C de Gooijer, Eloy Moreno Roig, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|August 25, 2016
PI3K-mTOR Pathway Inhibition Exhibits Efficacy Against High-grade Glioma in Clinically Relevant Mouse ModelsFan Lin, Mark C de Gooijer, Diana Hanekamp, et al.
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