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Bioorganic & Medicinal Chemistry Letters|February 15, 2002
Synthesis and anti-angiogenic activity of 6-(1,2,4-thiadiazol-5-yl)-3-amino pyridazine derivativesJean-Pierre Bongartz, Raymond Stokbroekx, Marcel Van der Aa, et al.
ACS Medicinal Chemistry Letters|November 20, 2020
A Chemical Probe for the Methyl Transferase PRMT5 with a Novel Binding ModeVineet Pande, Weimei Sun, Lijs Beke, et al.
Bioorganic & Medicinal Chemistry Letters|November 4, 2019
Discovery and optimization of a series of small-molecule allosteric inhibitors of MALT1 proteaseTianbao Lu, Peter J Connolly, Ulrike Philippar, et al.
Chemmedchem|August 26, 2009
Design and synthesis of a series of piperazine-1-carboxamidine derivatives with antifungal activity resulting from accumulation of endogenous reactive oxygen speciesIsabelle E François, Karin Thevissen, Klaartje Pellens, et al.
Journal of Medicinal Chemistry|January 20, 2021
Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC)Zhuming Zhang, Peter J Connolly, Heng Keang Lim, et al.
Molecular Cancer Therapeutics|March 2, 2021
Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate CancerJonathan R Branch, Tammy L Bush, Vineet Pande, et al.
Bioscience Reports|October 4, 2015
MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cellsLijs Beke, Cenk Kig, Joannes T M Linders, et al.
Bioorganic & Medicinal Chemistry Letters|May 22, 2018
Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapyTianbao Lu, Carsten Schubert, Maxwell D Cummings, et al.
ACS Medicinal Chemistry Letters|January 16, 2015
Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinaseChristopher N Johnson, Valerio Berdini, Lijs Beke, et al.
ACS Medicinal Chemistry Letters|January 16, 2015
Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper KinaseChristopher N Johnson, Christophe Adelinet, Valerio Berdini, et al.
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