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Molecules (Basel, Switzerland)|December 1, 2020
Inhibiting the NLRP3 InflammasomeLina Y El-Sharkawy, David Brough, Sally FreemanIscience|May 22, 2023
Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasomeJack P Green, Lina Y El-Sharkawy, Stefan Roth, et al.Journal of Medicinal Chemistry|October 1, 2015
Inhibiting the Inflammasome: A Chemical PerspectiveAlex G Baldwin, David Brough, Sally FreemanElife|November 20, 2020
LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activationJack P Green, Tessa Swanton, Lucy V Morris, et al.Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents|March 13, 2018
Synthesis and antibacterial activities of enamine derivatives of dehydroacetic acidAlex G Baldwin, Jonathan Bevan, David Brough, et al.SLAS Discovery : Advancing Life Sciences R & D|July 4, 2018
Is Targeting the Inflammasome a Way Forward for Neuroscience Drug Discovery?Tessa Swanton, James Cook, James A Beswick, et al.Bioorganic Chemistry|October 28, 2024
Virtual screening-led design of inhibitor scaffolds for the NLRP3 inflammasomeSherihan El-Sayed, Emily McMahon, Sondos Musleh, et al.Chemmedchem|January 14, 2018
Design, Synthesis and Evaluation of Oxazaborine Inhibitors of the NLRP3 InflammasomeAlex G Baldwin, Victor S Tapia, Tessa Swanton, et al.Bioorganic Chemistry|March 30, 2020
Synthesis of novel 1,2-diarylpyrazolidin-3-one-based compounds and their evaluation as broad spectrum antibacterial agentsSalma A Mokbel, Reem K Fathalla, Lina Y El-Sharkawy, et al.Cell Death Discovery|December 21, 2023
Squaramides enhance NLRP3 inflammasome activation by lowering intracellular potassiumPaula I Seoane, James A Beswick, Andrew G Leach, et al.Pageof 20