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Methods in Enzymology|January 22, 2023
Optimized protocols for the characterization of Cas12a activitiesLindsie Martin, Saadi Rostami, Rakhi RajanBiochemical and Biophysical Research Communications|May 17, 2026
Helicity of the bridge helix of Cas12a regulates on-target DNA cleavage efficiency and off-target cleavage propensityLindsie Martin, Saadi Rostami, Isabelle Schuster, et al.Frontiers in Cellular and Infection Microbiology|February 15, 2021
The CRISPR-Cas Mechanism for Adaptive Immunity and Alternate Bacterial Functions Fuels Diverse BiotechnologiesSydney Newsom, Hari Priya Parameshwaran, Lindsie Martin, et al.The Journal of Biological Chemistry|April 19, 2024
Unity among the diverse RNA-guided CRISPR-Cas interference mechanismsChhandosee Ganguly, Saadi Rostami, Kole Long, et al.Biorxiv : the Preprint Server for Biology|January 20, 2025
Helical transition of the bridge helix of Cas12a is an allosteric regulator of R-loop formation and RuvC activationChhandosee Ganguly, Lindsie Martin, Swarmistha Aribam, et al.Biochemistry|December 16, 2024
Exploring CRISPR-Cas9 HNH-Domain-Catalyzed DNA Cleavage Using Accelerated Quantum Mechanical Molecular Mechanical Free Energy SimulationRichard Van, Xiaoliang Pan, Saadi Rostami, et al.Nature Communications|January 28, 2026
Bridge helix of Cas12a is an allosteric regulator of R-loop formation and RuvC activationChhandosee Ganguly, Swarmistha Devi Aribam, Alberto Monteiro Dos Santos, et al.The CRISPR Journal|December 18, 2023
Differential Divalent Metal Binding by SpyCas9's RuvC Active Site Contributes to Nonspecific DNA CleavageSydney N Newsom, Duen-Shian Wang, Saadi Rostami, et al.Advances in Experimental Medicine and Biology|July 19, 2022
Molecular Details of DNA Integration by CRISPR-Associated Proteins During Adaptation in Bacteria and ArchaeaTamara Flusche, Rakhi RajanJournal of Molecular Biology|November 17, 2004
Crystal structure of RecA from Deinococcus radiodurans: insights into the structural basis of extreme radioresistanceRakhi Rajan, Charles E BellPageof 4