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Bioorganic & Medicinal Chemistry
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October 5, 2011
Improvement in oral bioavailability of 2,4-diaminopyrimidine c-Met inhibitors by incorporation of a 3-amidobenzazepin-2-one group
Karen L Milkiewicz, Lisa D Aimone, Mark S Albom, et al.
ACS Medicinal Chemistry Letters
|
June 6, 2014
Discovery of a potent inhibitor of anaplastic lymphoma kinase with in vivo antitumor activity
Gregory R Ott, Rabindranath Tripathy, Mangeng Cheng, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
October 18, 2011
CEP-26401 (irdabisant), a potent and selective histamine H₃ receptor antagonist/inverse agonist with cognition-enhancing and wake-promoting activities
Rita Raddatz, Robert L Hudkins, Joanne R Mathiasen, et al.
Journal of Medicinal Chemistry
|
December 4, 2003
A new class of potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: structure-activity relationships for a series of 9-alkoxymethyl-12-(3-hydroxypropyl)indeno[2,1-a]pyrrolo[3,4-c]carbazole-5-ones and the identification of CEP-5214 and its dimethylglycine ester prodrug clinical candidate CEP-7055
Diane E Gingrich, Dandu R Reddy, Mohamed A Iqbal, et al.
Journal of Medicinal Chemistry
|
December 14, 2011
Synthesis and biological profile of the pan-vascular endothelial growth factor receptor/tyrosine kinase with immunoglobulin and epidermal growth factor-like homology domains 2 (VEGF-R/TIE-2) inhibitor 11-(2-methylpropyl)-12,13-dihydro-2-methyl-8-(pyrimidin-2-ylamino)-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one (CEP-11981): a novel oncology therapeutic agent
Robert L Hudkins, Nadine C Becknell, Allison L Zulli, et al.
Bioorganic & Medicinal Chemistry Letters
|
February 7, 2015
Piperidine-3,4-diol and piperidine-3-ol derivatives of pyrrolo[2,1-f][1,2,4]triazine as inhibitors of anaplastic lymphoma kinase
Eugen F Mesaros, Thelma S Angeles, Mark S Albom, et al.
Bioorganic & Medicinal Chemistry Letters
|
November 16, 2010
Novel 2,3,4,5-tetrahydro-benzo[d]azepine derivatives of 2,4-diaminopyrimidine, selective and orally bioavailable ALK inhibitors with antitumor efficacy in ALCL mouse models
Eugen F Mesaros, Jason P Burke, Jonathan D Parrish, et al.
Bioorganic & Medicinal Chemistry Letters
|
July 26, 2011
Identification of pyridazin-3-one derivatives as potent, selective histamine H₃ receptor inverse agonists with robust wake activity
Robert L Hudkins, Lisa D Aimone, Thomas R Bailey, et al.
Journal of Medicinal Chemistry
|
May 9, 2012
Discovery of an orally efficacious inhibitor of anaplastic lymphoma kinase
Diane E Gingrich, Joseph G Lisko, Matthew A Curry, et al.
Journal of Medicinal Chemistry
|
August 24, 2011
2,7-disubstituted-pyrrolo[2,1-f][1,2,4]triazines: new variant of an old template and application to the discovery of anaplastic lymphoma kinase (ALK) inhibitors with in vivo antitumor activity
Gregory R Ott, Gregory J Wells, Tho V Thieu, et al.
Page
of 5
Search research articles
Search
Showing results (31-40 of 48) with videos related to
Sort By:
Page
of 5
Bioorganic & Medicinal Chemistry
|
October 5, 2011
Improvement in oral bioavailability of 2,4-diaminopyrimidine c-Met inhibitors by incorporation of a 3-amidobenzazepin-2-one group
Karen L Milkiewicz, Lisa D Aimone, Mark S Albom, et al.
ACS Medicinal Chemistry Letters
|
June 6, 2014
Discovery of a potent inhibitor of anaplastic lymphoma kinase with in vivo antitumor activity
Gregory R Ott, Rabindranath Tripathy, Mangeng Cheng, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
October 18, 2011
CEP-26401 (irdabisant), a potent and selective histamine H₃ receptor antagonist/inverse agonist with cognition-enhancing and wake-promoting activities
Rita Raddatz, Robert L Hudkins, Joanne R Mathiasen, et al.
Journal of Medicinal Chemistry
|
December 4, 2003
A new class of potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: structure-activity relationships for a series of 9-alkoxymethyl-12-(3-hydroxypropyl)indeno[2,1-a]pyrrolo[3,4-c]carbazole-5-ones and the identification of CEP-5214 and its dimethylglycine ester prodrug clinical candidate CEP-7055
Diane E Gingrich, Dandu R Reddy, Mohamed A Iqbal, et al.
Journal of Medicinal Chemistry
|
December 14, 2011
Synthesis and biological profile of the pan-vascular endothelial growth factor receptor/tyrosine kinase with immunoglobulin and epidermal growth factor-like homology domains 2 (VEGF-R/TIE-2) inhibitor 11-(2-methylpropyl)-12,13-dihydro-2-methyl-8-(pyrimidin-2-ylamino)-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one (CEP-11981): a novel oncology therapeutic agent
Robert L Hudkins, Nadine C Becknell, Allison L Zulli, et al.
Bioorganic & Medicinal Chemistry Letters
|
February 7, 2015
Piperidine-3,4-diol and piperidine-3-ol derivatives of pyrrolo[2,1-f][1,2,4]triazine as inhibitors of anaplastic lymphoma kinase
Eugen F Mesaros, Thelma S Angeles, Mark S Albom, et al.
Bioorganic & Medicinal Chemistry Letters
|
November 16, 2010
Novel 2,3,4,5-tetrahydro-benzo[d]azepine derivatives of 2,4-diaminopyrimidine, selective and orally bioavailable ALK inhibitors with antitumor efficacy in ALCL mouse models
Eugen F Mesaros, Jason P Burke, Jonathan D Parrish, et al.
Bioorganic & Medicinal Chemistry Letters
|
July 26, 2011
Identification of pyridazin-3-one derivatives as potent, selective histamine H₃ receptor inverse agonists with robust wake activity
Robert L Hudkins, Lisa D Aimone, Thomas R Bailey, et al.
Journal of Medicinal Chemistry
|
May 9, 2012
Discovery of an orally efficacious inhibitor of anaplastic lymphoma kinase
Diane E Gingrich, Joseph G Lisko, Matthew A Curry, et al.
Journal of Medicinal Chemistry
|
August 24, 2011
2,7-disubstituted-pyrrolo[2,1-f][1,2,4]triazines: new variant of an old template and application to the discovery of anaplastic lymphoma kinase (ALK) inhibitors with in vivo antitumor activity
Gregory R Ott, Gregory J Wells, Tho V Thieu, et al.
Page
of 5