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Journal of Medicinal Chemistry|January 2, 2025
Discovery of SMD-3236: A Potent, Highly Selective and Efficacious SMARCA2 Degrader for the Treatment of SMARC4-Deficient Human CancersLin Yang, Wenbin Tu, Lingying Leng, et al.Journal of Medicinal Chemistry|June 13, 2017
Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein InteractionHacer Karatas, Yangbing Li, Liu Liu, et al.Bioorganic & Medicinal Chemistry Letters|September 16, 2008
Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant alpha4beta2 nicotinic acetylcholine receptor potentiatorsBrian K Albrecht, Virginia Berry, Alessandro A Boezio, et al.Bioorganic & Medicinal Chemistry Letters|July 22, 2008
Structural modifications of N-arylamide oxadiazoles: Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2Erin F DiMauro, John L Buchanan, Alan Cheng, et al.Bioorganic & Medicinal Chemistry Letters|January 3, 2012
Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonistsHanh Nho Nguyen, Howie Bregman, John L Buchanan, et al.Journal of Medicinal Chemistry|November 21, 2024
Discovery of Potent, Highly Selective, and Efficacious SMARCA2 DegradersZhenwu Li, Lalgudi S Harikrishnan, Guozhang Xu, et al.Journal of Medicinal Chemistry|June 17, 2008
Discovery of a potent, selective, and orally bioavailable c-Met inhibitor: 1-(2-hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458)Longbin Liu, Aaron Siegmund, Ning Xi, et al.Journal of Medicinal Chemistry|May 25, 2013
Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitorsHoward Bregman, Nagasree Chakka, Angel Guzman-Perez, et al.Journal of Medicinal Chemistry|July 19, 2018
Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor RegressionChong Qin, Yang Hu, Bing Zhou, et al.Journal of Medicinal Chemistry|December 22, 2016
The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine ReceptorsHoward Bregman, Jeffrey R Simard, Kristin L Andrews, et al.Pageof 7