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The Journal of Neuroscience : the Official Journal of the Society for Neuroscience|May 1, 2015
Centrally Delivered BACE1 Inhibitor Activates Microglia, and Reverses Amyloid Pathology and Cognitive Deficit in Aged Tg2576 MiceDeepak R Thakker, Sethu Sankaranarayanan, Marcy R Weatherspoon, et al.The Journal of Pharmacology and Experimental Therapeutics|June 25, 2020
p38<i>α</i> Regulates Expression of DUX4 in a Model of Facioscapulohumeral Muscular DystrophyL Alejandro Rojas, Erin Valentine, Anthony Accorsi, et al.European Journal of Pharmacology|July 11, 2017
Synergistic inhibition of Aβ production by combinations of γ-secretase modulatorsAlan S Robertson, Lawrence G Iben, Cong Wei, et al.Bioorganic & Medicinal Chemistry Letters|January 15, 2019
Discovery of new indole-based acylsulfonamide Na<sub>v</sub>1.7 inhibitorsYong-Jin Wu, Brian Venables, Jason Guernon, et al.Bioorganic & Medicinal Chemistry Letters|September 5, 2020
Synthesis of functionalized derivatives of the gamma-secretase modulator BMS-932481 and identification of its major metaboliteYunhui Zhang, Kenneth M Boy, Yong-Jin Wu, et al.Journal of Medicinal Chemistry|August 26, 2016
Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine β-Site APP Cleaving Enzyme-1 (BACE1) InhibitorsYong-Jin Wu, Jason Guernon, Jianliang Shi, et al.Bioorganic & Medicinal Chemistry Letters|May 16, 2007
Design and synthesis of benzoazepinone-derived cyclic malonamides and aminoamides as potent gamma-secretase inhibitorsMichael G Yang, Jian-Liang Shi, Dilip P Modi, et al.Bioorganic & Medicinal Chemistry Letters|February 15, 2018
Discovery of morpholine-based aryl sulfonamides as Na<sub>v</sub>1.7 inhibitorsYong-Jin Wu, Jason Guernon, Andrea McClure, et al.Bioorganic & Medicinal Chemistry Letters|February 5, 2003
Both 5-arylidene-2-thioxodihydropyrimidine-4,6(1H,5H)-diones and 3-thioxo-2,3-dihydro-1H-imidazo[1,5-a]indol-1-ones are light-dependent tumor necrosis factor-alpha antagonistsMatthew E Voss, Percy H Carter, Andrew J Tebben, et al.ACS Medicinal Chemistry Letters|March 18, 2016
Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in RodentsYong-Jin Wu, Jason Guernon, Fukang Yang, et al.Pageof 4