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British Journal of Clinical Pharmacology|May 1, 2021
Phase 1 clinical trial of losmapimod in facioscapulohumeral dystrophy: Safety, tolerability, pharmacokinetics, and target engagementMichelle L Mellion, Lucienne Ronco, Cecile L Berends, et al.Bioorganic & Medicinal Chemistry Letters|February 14, 2006
Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitorsLorin A Thompson, Ann Y Liauw, Mercy M Ramanjulu, et al.Bioorganic & Medicinal Chemistry Letters|October 27, 2015
Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE)Kenneth M Boy, Jason M Guernon, Yong-Jin Wu, et al.Bioorganic & Medicinal Chemistry Letters|July 26, 2011
Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE)Kenneth M Boy, Jason M Guernon, Jianliang Shi, et al.Journal of Medicinal Chemistry|December 22, 2018
Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective Na<sub>V</sub>1.7 Inhibitors for the Treatment of PainGuanglin Luo, Ling Chen, Amy Easton, et al.The Journal of Pharmacology and Experimental Therapeutics|May 19, 2016
The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy VolunteersHolly D Soares, Maciej Gasior, Jeremy H Toyn, et al.Bioorganic & Medicinal Chemistry|August 19, 2017
Discovery of non-zwitterionic aryl sulfonamides as Na<sub>v</sub>1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activationYong-Jin Wu, Jason Guernon, Andrea McClure, et al.Journal of Medicinal Chemistry|February 25, 2017
Development of New Benzenesulfonamides As Potent and Selective Na<sub>v</sub>1.7 Inhibitors for the Treatment of PainYong-Jin Wu, Jason Guernon, Jianliang Shi, et al.Journal of Medicinal Chemistry|October 4, 2012
Acyl guanidine inhibitors of β-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesisSamuel W Gerritz, Weixu Zhai, Shuhao Shi, et al.The Journal of Pharmacology and Experimental Therapeutics|May 24, 2008
P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in miceJere E Meredith, Lorin A Thompson, Jeremy H Toyn, et al.Pageof 4