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Journal of Medicinal Chemistry|October 29, 2021
DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral LeishmaniasisCharles E Mowbray, Stéphanie Braillard, Paul A Glossop, et al.European Journal of Medicinal Chemistry|December 2, 2022
Hit-to-lead optimization of a 2-aminobenzimidazole series as new candidates for chagas diseaseCelso de Oliveira Rezende Júnior, Pablo David Grigol Martinez, Rafael Augusto Alves Ferreira, et al.The Journal of Antimicrobial Chemotherapy|December 21, 2019
Evaluation of phthalazinone phosphodiesterase inhibitors with improved activity and selectivity against Trypanosoma cruziJulianna Siciliano De Araújo, Patrícia Bernardino da Silva, Marcos Meuser Batista, et al.The Journal of Antimicrobial Chemotherapy|May 11, 2026
A strategic discovery roadmap towards high-quality leads and drug development candidates for kinetoplastid diseases. Part 3: from lead towards a drug development candidateSarah Hendrickx, Kayhan Ilbeigi, Eli S J Thoré, et al.International Journal of Molecular Sciences|April 13, 2023
To Target or Not to Target Schistosoma mansoni Cyclic Nucleotide Phosphodiesterase 4A?Yang Zheng, Susanne Schroeder, Georgi K Kanev, et al.Plos Neglected Tropical Diseases|February 22, 2021
2-aminobenzimidazoles for leishmaniasis: From initial hit discovery to in vivo profilingRafael Augusto Alves Ferreira, Celso de Oliveira Rezende Junior, Pablo David Grigol Martinez, et al.Bioorganic & Medicinal Chemistry|July 23, 2019
Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitorsErik de Heuvel, Abhimanyu K Singh, Ewald Edink, et al.International Journal for Parasitology. Drugs and Drug Resistance|January 23, 2019
Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activitySanaa S Botros, Samia William, Abdel-Nasser A Sabra, et al.Elife|March 23, 2016
Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinentHideo Imamura, Tim Downing, Frederik Van den Broeck, et al.Journal of Medicinal Chemistry|April 20, 2018
Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal ActivityAntoni R Blaazer, Abhimanyu K Singh, Erik de Heuvel, et al.Pageof 27