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Molecular Therapy. Nucleic Acids|October 11, 2021
Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scopeLukas Villiger, Lukas Schmidheini, Nicolas Mathis, et al.Biosensors|March 24, 2022
Self-Assembly of Nanodiamonds and Plasmonic Nanoparticles for NanoscopyLukas Schmidheini, Raphael F Tiefenauer, Volker Gatterdam, et al.Nature Biotechnology|January 16, 2023
Predicting prime editing efficiency and product purity by deep learningNicolas Mathis, Ahmed Allam, Lucas Kissling, et al.ACS Sensors|July 17, 2019
Dark-Field Microwells toward High-Throughput Direct miRNA Sensing with Gold NanoparticlesStephanie Hwu, Yves Blickenstorfer, Raphael F Tiefenauer, et al.Nature Chemical Biology|September 21, 2023
Continuous directed evolution of a compact CjCas9 variant with broad PAM compatibilityLukas Schmidheini, Nicolas Mathis, Kim Fabiano Marquart, et al.Science Translational Medicine|March 16, 2022
In vivo prime editing of a metabolic liver disease in miceDesirée Böck, Tanja Rothgangl, Lukas Villiger, et al.Nature Biotechnology|June 21, 2024
Machine learning prediction of prime editing efficiency across diverse chromatin contextsNicolas Mathis, Ahmed Allam, András Tálas, et al.Science Translational Medicine|May 13, 2026
Prime editing of a pathogenic Scn1a allele ameliorates seizure phenotypes in a GEFS+ mouse modelLucas Kissling, Francesca Pietrafesa, Matteo Ranucci, et al.Nature Methods|September 23, 2024
Effective genome editing with an enhanced ISDra2 TnpB system and deep learning-predicted ωRNAsKim Fabiano Marquart, Nicolas Mathis, Amina Mollaysa, et al.Nature Biomedical Engineering|May 20, 2025
Treatment of a metabolic liver disease in mice with a transient prime editing approachTanja Rothgangl, András Tálas, Eleonora I Ioannidi, et al.Pageof 2