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Human Molecular Genetics|May 23, 2023
ALS-linked CCNF variant disrupts motor neuron ubiquitin homeostasisNatalie E Farrawell, Monique Bax, Luke McAlary, et al.
Molecular Neurodegeneration|March 28, 2020
Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein EJerome Robert, Emily B Button, Emma M Martin, et al.
Glia|October 10, 2019
The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteinsVandana Deora, John D Lee, Eduardo A Albornoz, et al.
Nucleic Acids Research|February 21, 2024
RNA-binding properties orchestrate TDP-43 homeostasis through condensate formation in vivoNatalie M Scherer, Cindy Maurel, Matthew S Graus, et al.
Ebiomedicine|April 13, 2025
A polytherapy approach demonstrates therapeutic efficacy for the treatment of SOD1 associated amyotrophic lateral sclerosisJeremy S Lum, Mikayla L Brown, Natalie E Farrawell, et al.
The Journal of Biological Chemistry|January 13, 2019
CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1Judith M Silverman, Darren Christy, Chih Cheih Shyu, et al.
Scientific Reports|September 30, 2021
CuATSM improves motor function and extends survival but is not tolerated at a high dose in SOD1G93A mice with a C57BL/6 backgroundJeremy S Lum, Mikayla L Brown, Natalie E Farrawell, et al.
Nature Communications|November 10, 2025
Development of a targeted BioPROTAC degrader selective for misfolded SOD1Christen G Chisholm, Rachael Bartlett, Mikayla L Brown, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society|December 7, 2024
Lipid nanoparticles and transcranial focused ultrasound enhance the delivery of SOD1 antisense oligonucleotides to the murine brain for ALS therapyGayathri R Ediriweera, Amal J Sivaram, Gary Cowin, et al.
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