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Nature Metabolism|June 2, 2020
Resolution of NASH and hepatic fibrosis by the GLP-1R/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesisMichelle L Boland, Rhianna C Laker, Karly Mather, et al.Nature Metabolism|December 8, 2023
Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetesVictoria E R Parker, Darren Robertson, Edmundo Erazo-Tapia, et al.Cardiovascular Research|March 4, 2025
A novel long-acting relaxin-2 fusion, AZD3427, improves cardiac performance in non-human primates with cardiac dysfunctionMonika Papworth, Spoorthy Kulkarni, Madeleine Antonsson, et al.Oncotarget|September 15, 2016
Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapyGeoffrey S Williams, Bina Mistry, Sandrine Guillard, et al.Plos One|December 22, 2016
A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development PropertiesAndrew C Nyborg, Chris Ward, Anna Zacco, et al.Journal of Immunology (Baltimore, Md. : 1950)|November 25, 2016
A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn BindingJulie Douthwaite, Jacques Moisan, Cyril Privezentzev, et al.Kidney International|September 1, 2024
A randomized phase 2b trial examined the effects of the glucagon-like peptide-1 and glucagon receptor agonist cotadutide on kidney outcomes in patients with diabetic kidney diseaseViknesh Selvarajah, Darren Robertson, Lars Hansen, et al.Diabetes|April 15, 2017
Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty RatsJames L Trevaskis, Chester Bittencourt Sacramento, Hani Jouihan, et al.Nature Communications|November 28, 2024
The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalkM Pilar Valdecantos, Laura Ruiz, Cintia Folgueira, et al.Pageof 7