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ACS Medicinal Chemistry Letters
|
June 6, 2014
Nexus between protein-ligand affinity rank-ordering, biophysical approaches, and drug discovery
M Ashley Spies
Biochemistry
|
April 30, 2003
Multiple hydrogen kinetic isotope effects for enzymes catalyzing exchange with solvent: application to alanine racemase
M Ashley Spies, Michael D Toney
Journal of the American Chemical Society
|
November 21, 2002
The trapping of a spontaneously "flipped-out" base from double helical nucleic acids by host-guest complexation with beta-cyclodextrin: the intrinsic base-flipping rate constant for DNA and RNA
M Ashley Spies, Richard L Schowen
Journal of the American Chemical Society
|
August 19, 2007
Intrinsic primary and secondary hydrogen kinetic isotope effects for alanine racemase from global analysis of progress curves
M Ashley Spies, Michael D Toney
Journal of Chemical Information and Modeling
|
October 12, 2013
Flooding enzymes: quantifying the contributions of interstitial water and cavity shape to ligand binding using extended linear response free energy calculations
Katie L Whalen, M Ashley Spies
Biochimica Et Biophysica Acta. General Subjects
|
June 10, 2018
Determinants of human glucokinase activation and implications for small molecule allosteric control
Quinn Li, Lokesh Gakhar, M Ashley Spies
Cell Chemical Biology
|
September 23, 2017
Small-Molecule Inhibitors Targeting DNA Repair and DNA Repair Deficiency in Research and Cancer Therapy
Sarah R Hengel, M Ashley Spies, Maria Spies
DNA Repair
|
November 3, 2022
A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein
Divya S Bhat, M Ashley Spies, Maria Spies
Angewandte Chemie (International Ed. in English)
|
September 24, 2017
Allosteric Tuning of Caspase-7: A Fragment-Based Drug Discovery Approach
Nicholas R Vance, Lokesh Gakhar, M Ashley Spies
ACS Central Science
|
November 6, 2015
Biosynthesis of a Novel Glutamate Racemase Containing a Site-Specific 7-Hydroxycoumarin Amino Acid: Enzyme-Ligand Promiscuity Revealed at the Atomistic Level
Sondra F Dean, Katie L Whalen, M Ashley Spies
Page
of 4
Search research articles
Search
Showing results (1-10 of 38) with videos related to
Sort By:
Page
of 4
ACS Medicinal Chemistry Letters
|
June 6, 2014
Nexus between protein-ligand affinity rank-ordering, biophysical approaches, and drug discovery
M Ashley Spies
Biochemistry
|
April 30, 2003
Multiple hydrogen kinetic isotope effects for enzymes catalyzing exchange with solvent: application to alanine racemase
M Ashley Spies, Michael D Toney
Journal of the American Chemical Society
|
November 21, 2002
The trapping of a spontaneously "flipped-out" base from double helical nucleic acids by host-guest complexation with beta-cyclodextrin: the intrinsic base-flipping rate constant for DNA and RNA
M Ashley Spies, Richard L Schowen
Journal of the American Chemical Society
|
August 19, 2007
Intrinsic primary and secondary hydrogen kinetic isotope effects for alanine racemase from global analysis of progress curves
M Ashley Spies, Michael D Toney
Journal of Chemical Information and Modeling
|
October 12, 2013
Flooding enzymes: quantifying the contributions of interstitial water and cavity shape to ligand binding using extended linear response free energy calculations
Katie L Whalen, M Ashley Spies
Biochimica Et Biophysica Acta. General Subjects
|
June 10, 2018
Determinants of human glucokinase activation and implications for small molecule allosteric control
Quinn Li, Lokesh Gakhar, M Ashley Spies
Cell Chemical Biology
|
September 23, 2017
Small-Molecule Inhibitors Targeting DNA Repair and DNA Repair Deficiency in Research and Cancer Therapy
Sarah R Hengel, M Ashley Spies, Maria Spies
DNA Repair
|
November 3, 2022
A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein
Divya S Bhat, M Ashley Spies, Maria Spies
Angewandte Chemie (International Ed. in English)
|
September 24, 2017
Allosteric Tuning of Caspase-7: A Fragment-Based Drug Discovery Approach
Nicholas R Vance, Lokesh Gakhar, M Ashley Spies
ACS Central Science
|
November 6, 2015
Biosynthesis of a Novel Glutamate Racemase Containing a Site-Specific 7-Hydroxycoumarin Amino Acid: Enzyme-Ligand Promiscuity Revealed at the Atomistic Level
Sondra F Dean, Katie L Whalen, M Ashley Spies
Page
of 4