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Chemistry (Weinheim an Der Bergstrasse, Germany)
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January 17, 2019
Evaluation of 1,2,3-Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX-770 and VX-809
Jake E Doiron, Christina A Le, Britton K Ody, et al.
Bioorganic & Medicinal Chemistry Letters
|
July 18, 2015
Further optimization of the mGlu5 PAM clinical candidate VU0409551/JNJ-46778212: Progress and challenges towards a back-up compound
Ya Zhou, Chrysa Malosh, Susana Conde-Ceide, et al.
Proceedings of the National Academy of Sciences of the United States of America
|
October 29, 2015
Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice
Tristano Pancani, Daniel J Foster, Mark S Moehle, et al.
Bioorganic & Medicinal Chemistry Letters
|
October 28, 2021
Discovery of structurally distinct tricyclic M<sub>4</sub> positive allosteric modulator (PAM) chemotypes - Part 2
Madeline F Long, Rory A Capstick, Paul K Spearing, et al.
Bioorganic & Medicinal Chemistry Letters
|
April 18, 2012
Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor
Bruce J Melancon, Rocco D Gogliotti, James C Tarr, et al.
ACS Medicinal Chemistry Letters
|
September 27, 2017
Design and Synthesis of <i>N</i>-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu<sub>3</sub> NAMs
Julie L Engers, Katrina A Bollinger, Rebecca L Weiner, et al.
Bioorganic & Medicinal Chemistry Letters
|
November 27, 2012
Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia
Uyen Le, Bruce J Melancon, Thomas M Bridges, et al.
Bioorganic & Medicinal Chemistry Letters
|
June 26, 2014
Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency
Mark Turlington, Meredith J Noetzel, Thomas M Bridges, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
November 18, 2011
The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease
Carrie K Jones, Michael Bubser, Analisa D Thompson, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals
|
September 5, 2013
Heterotropic activation of the midazolam hydroxylase activity of CYP3A by a positive allosteric modulator of mGlu5: in vitro to in vivo translation and potential impact on clinically relevant drug-drug interactions
Anna L Blobaum, Thomas M Bridges, Frank W Byers, et al.
Page
of 41
Search research articles
Search
Showing results (351-360 of 403) with videos related to
Sort By:
Page
of 41
Chemistry (Weinheim an Der Bergstrasse, Germany)
|
January 17, 2019
Evaluation of 1,2,3-Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX-770 and VX-809
Jake E Doiron, Christina A Le, Britton K Ody, et al.
Bioorganic & Medicinal Chemistry Letters
|
July 18, 2015
Further optimization of the mGlu5 PAM clinical candidate VU0409551/JNJ-46778212: Progress and challenges towards a back-up compound
Ya Zhou, Chrysa Malosh, Susana Conde-Ceide, et al.
Proceedings of the National Academy of Sciences of the United States of America
|
October 29, 2015
Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice
Tristano Pancani, Daniel J Foster, Mark S Moehle, et al.
Bioorganic & Medicinal Chemistry Letters
|
October 28, 2021
Discovery of structurally distinct tricyclic M<sub>4</sub> positive allosteric modulator (PAM) chemotypes - Part 2
Madeline F Long, Rory A Capstick, Paul K Spearing, et al.
Bioorganic & Medicinal Chemistry Letters
|
April 18, 2012
Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor
Bruce J Melancon, Rocco D Gogliotti, James C Tarr, et al.
ACS Medicinal Chemistry Letters
|
September 27, 2017
Design and Synthesis of <i>N</i>-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu<sub>3</sub> NAMs
Julie L Engers, Katrina A Bollinger, Rebecca L Weiner, et al.
Bioorganic & Medicinal Chemistry Letters
|
November 27, 2012
Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia
Uyen Le, Bruce J Melancon, Thomas M Bridges, et al.
Bioorganic & Medicinal Chemistry Letters
|
June 26, 2014
Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency
Mark Turlington, Meredith J Noetzel, Thomas M Bridges, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
November 18, 2011
The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease
Carrie K Jones, Michael Bubser, Analisa D Thompson, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals
|
September 5, 2013
Heterotropic activation of the midazolam hydroxylase activity of CYP3A by a positive allosteric modulator of mGlu5: in vitro to in vivo translation and potential impact on clinically relevant drug-drug interactions
Anna L Blobaum, Thomas M Bridges, Frank W Byers, et al.
Page
of 41