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M Bridges

Showing results (391-400 of 403) with videos related to

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ACS Chemical Neuroscience|August 20, 2014
Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodentsMichael Bubser, Thomas M Bridges, Ditte Dencker, et al.
Bioorganic & Medicinal Chemistry Letters|December 20, 2015
Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophreniaSusana Conde-Ceide, Jesús Alcázar, Sergio A Alonso de Diego, et al.
Bioorganic & Medicinal Chemistry Letters|May 18, 2016
Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine coreMichael R Wood, Meredith J Noetzel, Julie L Engers, et al.
Journal of Medicinal Chemistry|October 17, 2025
Optimization of Selective and CNS Penetrant Alkyne-Based TREK Inhibitors: The Discovery and Characterization of ONO-9517601 (VU6022856) and ONO-7927846 (VU6024391)Motoyuki Tanaka, Yoko Sekioka, Gakuji Hashimoto, et al.
The Journal of Pharmacology and Experimental Therapeutics|August 23, 2013
N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancementK J Gregory, E J Herman, A J Ramsey, et al.
ACS Chemical Neuroscience|January 25, 2026
Discovery of VU6025733 (AG06827): A Highly Selective, Orally Bioavailable, and Structurally Distinct M<sub>4</sub> Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust <i>In Vivo</i> EfficacyAlison R Gregro, Charlotte Park, Madeline F Long, et al.
ACS Chemical Neuroscience|December 11, 2024
Discovery of VU0467319: an M<sub>1</sub> Positive Allosteric Modulator Candidate That Advanced into Clinical TrialsMichael S Poslunsey, Michael R Wood, Changho Han, et al.
Bioorganic & Medicinal Chemistry Letters|June 29, 2019
SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M<sub>4</sub> PAMsTrevor C Chopko, Changho Han, Alison R Gregro, et al.
Neuron|May 5, 2015
Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR CurrentsJerri M Rook, Zixiu Xiang, Xiaohui Lv, et al.
BMC Medical Education|November 22, 2017
Implementation of an interprofessional team-based learning program involving seven undergraduate health and social care programs from two universities, and students' evaluation of their readiness for interprofessional learningLap Ki Chan, Fraide Ganotice, Frances Kam Yuet Wong, et al.
Pageof 41

Showing results (391-400 of 403) with videos related to

Sort By:
Pageof 41
ACS Chemical Neuroscience|August 20, 2014
Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodentsMichael Bubser, Thomas M Bridges, Ditte Dencker, et al.
Bioorganic & Medicinal Chemistry Letters|December 20, 2015
Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophreniaSusana Conde-Ceide, Jesús Alcázar, Sergio A Alonso de Diego, et al.
Bioorganic & Medicinal Chemistry Letters|May 18, 2016
Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine coreMichael R Wood, Meredith J Noetzel, Julie L Engers, et al.
Journal of Medicinal Chemistry|October 17, 2025
Optimization of Selective and CNS Penetrant Alkyne-Based TREK Inhibitors: The Discovery and Characterization of ONO-9517601 (VU6022856) and ONO-7927846 (VU6024391)Motoyuki Tanaka, Yoko Sekioka, Gakuji Hashimoto, et al.
The Journal of Pharmacology and Experimental Therapeutics|August 23, 2013
N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancementK J Gregory, E J Herman, A J Ramsey, et al.
ACS Chemical Neuroscience|January 25, 2026
Discovery of VU6025733 (AG06827): A Highly Selective, Orally Bioavailable, and Structurally Distinct M<sub>4</sub> Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust <i>In Vivo</i> EfficacyAlison R Gregro, Charlotte Park, Madeline F Long, et al.
ACS Chemical Neuroscience|December 11, 2024
Discovery of VU0467319: an M<sub>1</sub> Positive Allosteric Modulator Candidate That Advanced into Clinical TrialsMichael S Poslunsey, Michael R Wood, Changho Han, et al.
Bioorganic & Medicinal Chemistry Letters|June 29, 2019
SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M<sub>4</sub> PAMsTrevor C Chopko, Changho Han, Alison R Gregro, et al.
Neuron|May 5, 2015
Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR CurrentsJerri M Rook, Zixiu Xiang, Xiaohui Lv, et al.
BMC Medical Education|November 22, 2017
Implementation of an interprofessional team-based learning program involving seven undergraduate health and social care programs from two universities, and students' evaluation of their readiness for interprofessional learningLap Ki Chan, Fraide Ganotice, Frances Kam Yuet Wong, et al.
Pageof 41