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Archives of Biochemistry and Biophysics|March 9, 1999
Application of a thermodynamic model to the prediction of phase separations in freeze-concentrated formulations for protein lyophilizationM C Heller, J F Carpenter, T W RandolphBiotechnology and Bioengineering|April 1, 1999
Protein formulation and lyophilization cycle design: prevention of damage due to freeze-concentration induced phase separationM C Heller, J F Carpenter, T W RandolphJournal of Pharmaceutical Sciences|December 1, 1996
Effects of phase separating systems on lyophilized hemoglobinM C Heller, J F Carpenter, T W RandolphBiotechnology Progress|October 23, 1997
Manipulation of lyophilization-induced phase separation: implications for pharmaceutical proteinsM C Heller, J F Carpenter, T W RandolphJournal of Pharmaceutical Sciences|January 6, 1999
Conformational stability of lyophilized PEGylated proteins in a phase-separating systemM C Heller, J F Carpenter, T W RandolphThe Journal of Biological Chemistry|June 29, 2000
Entrapping intermediates of thermal aggregation in alpha-helical proteins with low concentration of guanidine hydrochlorideA Dong, T W Randolph, J F CarpenterBiotechnology Progress|August 10, 2000
Stability of subtilisin and lysozyme under high hydrostatic pressureJ N Webb, J F Carpenter, T W RandolphJournal of Pharmaceutical Sciences|July 18, 2001
The ice nucleation temperature determines the primary drying rate of lyophilization for samples frozen on a temperature-controlled shelfJ A Searles, J F Carpenter, T W RandolphJournal of Pharmaceutical Sciences|July 18, 2001
Annealing to optimize the primary drying rate, reduce freezing-induced drying rate heterogeneity, and determine T(g)' in pharmaceutical lyophilizationJ A Searles, J F Carpenter, T W RandolphProceedings of the National Academy of Sciences of the United States of America|November 11, 1999
High pressure fosters protein refolding from aggregates at high concentrationsR J St John, J F Carpenter, T W RandolphPageof 13