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Protein Expression and Purification|February 1, 1996
Recombinant human renin produced in different expression systems: biochemical properties and 3D structureS Mathews, H Döbeli, M Pruschy, et al.
American Journal of Hypertension|July 1, 1991
Nonparallel effects of renin inhibitor treatment on plasma renin activity and angiotensins I and II in hypertensive subjects. An assay-related artifactF H Derkx, A H van den Meiracker, W Fischli, et al.
European Journal of Biochemistry|July 1, 1995
Separable binding sites for the natural agonist endothelin-1 and the non-peptide antagonist bosentan on human endothelin-A receptorsV Breu, K Hashido, C Broger, et al.
The Journal of Pharmacology and Experimental Therapeutics|July 1, 1994
Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonistM Clozel, V Breu, G A Gray, et al.
Circulation|November 24, 1998
Hemodynamic and coronary effects of the endothelin antagonist bosentan in patients with coronary artery diseaseR R Wenzel, M Fleisch, S Shaw, et al.
Bioorganic & Medicinal Chemistry Letters|June 9, 1999
Substituted piperidines--highly potent renin inhibitors due to induced fit adaptation of the active siteE Vieira, A Binggeli, V Breu, et al.
Bioorganic & Medicinal Chemistry Letters|June 9, 1999
Piperidine-renin inhibitors compounds with improved physicochemical propertiesR Güller, A Binggeli, V Breu, et al.
Chemistry & Biology|March 13, 1999
Renin inhibition by substituted piperidines: a novel paradigm for the inhibition of monomeric aspartic proteinases?C Oefner, A Binggeli, V Breu, et al.
The Journal of Biological Chemistry|November 21, 1998
A causative role for redox cycling of myoglobin and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis-induced renal failureK P Moore, S G Holt, R P Patel, et al.
Farmaco (Societa Chimica Italiana : 1989)|May 12, 2001
Piperidine renin inhibitors: from leads to drug candidatesH P Märki, A Binggeli, B Bittner, et al.
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