M J Camarasa - JoVE Visualize

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Journal of Medicinal Chemistry|July 24, 1992

3'-Spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: synthesis and antiviral activity of [2'-5'-bis-O-(tert-butyldimethylsilyl)-beta-D-xylo- and -ribofuranose]-3'-spiro-5"-[4"-amino-1",2"-oxathiole 2",2"-dioxide] (TSAO) pyrimidine nucleosidesM J Camarasa, M J Pérez-Pérez, A San-Félix, et al.

Proceedings of the National Academy of Sciences of the United States of America|July 5, 1994

Human immunodeficiency virus 1 (HIV-1)-specific reverse transcriptase (RT) inhibitors may suppress the replication of specific drug-resistant (E138K)RT HIV-1 mutants or select for highly resistant (Y181C-->C181I)RT HIV-1 mutantsJ Balzarini, A Karlsson, V V Sardana, et al.

Antiviral Chemistry & Chemotherapy|January 6, 1999

Novel 3'-spiro nucleoside analogues of TSAO-T. Part II. A comparative study based on NMR conformational analysis in solution and theoretical calculationsR Alvarez, M L Jimeno, F Gago, et al.

Antiviral Chemistry & Chemotherapy|December 29, 1998

Regiospecific synthesis and anti-human immunodeficiency virus activity of novel 5-substituted N-alkylcarbamoyl and N,N-dialkylcarbamoyl 1,2,3-triazole-TSAO analoguesS Velázquez, R Alvarez, C Pérez, et al.

Journal of Virology|September 1, 1993

Treatment of human immunodeficiency virus type 1 (HIV-1)-infected cells with combinations of HIV-1-specific inhibitors results in a different resistance pattern than does treatment with single-drug therapyJ Balzarini, A Karlsson, M J Pérez-Pérez, et al.

Journal of Medicinal Chemistry|October 29, 1993

TSAO analogues. 3. Synthesis and anti-HIV-1 activity of 2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl 3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide) purine and purine-modified nucleosidesS Velázquez, A San-Félix, M J Pérez-Pérez, et al.

Journal of Medicinal Chemistry|March 15, 2000

Design, synthesis, and enzymatic evaluation of multisubstrate analogue inhibitors of Escherichia coli thymidine phosphorylaseA Esteban-Gamboa, J Balzarini, R Esnouf, et al.

The Journal of Biological Chemistry|May 17, 2001

Functional characterization of chimeric reverse transcriptases with polypeptide subunits of highly divergent HIV-1 group M and O strainsL Menéndez-Arias, A Abraha, M E Quiñones-Mateu, et al.

Antiviral Chemistry & Chemotherapy|January 6, 1999

An approach towards the synthesis of potential metal-chelating TSAO-T derivatives as bidentate inhibitors of human immunodeficiency virus type 1 reverse transcriptaseC Chamorro, M J Camarasa, M J Pérez-Pérez, et al.

Journal of Medicinal Chemistry|December 22, 1999

Potential multifunctional inhibitors of HIV-1 reverse transcriptase. Novel [AZT]-[TSAO-T] and [d4T]-[TSAO-T] heterodimers modified in the linker and in the dideoxynucleoside regionS Velázquez, V Tuñón, M L Jimeno, et al.

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Journal of Medicinal Chemistry|July 24, 1992

3'-Spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: synthesis and antiviral activity of [2'-5'-bis-O-(tert-butyldimethylsilyl)-beta-D-xylo- and -ribofuranose]-3'-spiro-5"-[4"-amino-1",2"-oxathiole 2",2"-dioxide] (TSAO) pyrimidine nucleosidesM J Camarasa, M J Pérez-Pérez, A San-Félix, et al.

Proceedings of the National Academy of Sciences of the United States of America|July 5, 1994

Human immunodeficiency virus 1 (HIV-1)-specific reverse transcriptase (RT) inhibitors may suppress the replication of specific drug-resistant (E138K)RT HIV-1 mutants or select for highly resistant (Y181C-->C181I)RT HIV-1 mutantsJ Balzarini, A Karlsson, V V Sardana, et al.

Antiviral Chemistry & Chemotherapy|January 6, 1999

Novel 3'-spiro nucleoside analogues of TSAO-T. Part II. A comparative study based on NMR conformational analysis in solution and theoretical calculationsR Alvarez, M L Jimeno, F Gago, et al.

Antiviral Chemistry & Chemotherapy|December 29, 1998

Regiospecific synthesis and anti-human immunodeficiency virus activity of novel 5-substituted N-alkylcarbamoyl and N,N-dialkylcarbamoyl 1,2,3-triazole-TSAO analoguesS Velázquez, R Alvarez, C Pérez, et al.

Journal of Virology|September 1, 1993

Treatment of human immunodeficiency virus type 1 (HIV-1)-infected cells with combinations of HIV-1-specific inhibitors results in a different resistance pattern than does treatment with single-drug therapyJ Balzarini, A Karlsson, M J Pérez-Pérez, et al.

Journal of Medicinal Chemistry|October 29, 1993

TSAO analogues. 3. Synthesis and anti-HIV-1 activity of 2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl 3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide) purine and purine-modified nucleosidesS Velázquez, A San-Félix, M J Pérez-Pérez, et al.

Journal of Medicinal Chemistry|March 15, 2000

Design, synthesis, and enzymatic evaluation of multisubstrate analogue inhibitors of Escherichia coli thymidine phosphorylaseA Esteban-Gamboa, J Balzarini, R Esnouf, et al.

The Journal of Biological Chemistry|May 17, 2001

Functional characterization of chimeric reverse transcriptases with polypeptide subunits of highly divergent HIV-1 group M and O strainsL Menéndez-Arias, A Abraha, M E Quiñones-Mateu, et al.

Antiviral Chemistry & Chemotherapy|January 6, 1999

An approach towards the synthesis of potential metal-chelating TSAO-T derivatives as bidentate inhibitors of human immunodeficiency virus type 1 reverse transcriptaseC Chamorro, M J Camarasa, M J Pérez-Pérez, et al.

Journal of Medicinal Chemistry|December 22, 1999

Potential multifunctional inhibitors of HIV-1 reverse transcriptase. Novel [AZT]-[TSAO-T] and [d4T]-[TSAO-T] heterodimers modified in the linker and in the dideoxynucleoside regionS Velázquez, V Tuñón, M L Jimeno, et al.

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