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Antimicrobial Agents and Chemotherapy|May 1, 1992
[2',5'-Bis-O-(tert-butyldimethylsilyl)]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) (TSAO) derivatives of purine and pyrimidinenucleosides as potent and selective inhibitors of human immunodeficiency virus type 1J Balzarini, M J Pérez-Pérez, A San-Félix, et al.Journal of Medicinal Chemistry|February 18, 1994
Novel series of TSAO-T derivatives. Synthesis and anti-HIV-1 activity of 4-, 5-, and 6-substituted pyrimidine analoguesA San-Félix, S Velázquez, M J Pérez-Pérez, et al.Current Pharmaceutical Design|May 27, 2006
TSAO derivatives, inhibitors of HIV-1 reverse transcriptase dimerization: recent progressM J Camarasa, S Velázquez, A San-Félix, et al.The Biochemical Journal|September 22, 2000
Novel ribofuranosylnucleoside lead compounds for potent and selective inhibitors of mitochondrial thymidine kinase-2J Balzarini, C Zhu, E De Clercq, et al.Journal of Medicinal Chemistry|May 12, 1995
Synthesis and anti-HIV activity of [AZT]-[TSAO-T] and [AZT]-[HEPT] dimers as potential multifunctional inhibitors of HIV-1 reverse transcriptaseS Velázquez, R Alvarez, A San-Félix, et al.Molecular Pharmacology|November 1, 1996
Differences in the inhibition of human immunodeficiency virus type 1 reverse transcriptase DNA polymerase activity by analogs of nevirapine and [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5"-(4"-amino-1", 2"-oxathiole-2",2"-dioxide] (TSAO)D Arion, R S Fletcher, G Borkow, et al.Molecular Pharmacology|January 1, 1993
Human immunodeficiency virus type 1-specific [2',5'-bis-O-(tert- butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5"-(4"-amino-1",2"- oxathiole-2",2"-dioxide)-purine analogues show a resistance spectrum that is different from that of the human immunodeficiency virus type 1-specific non-nucleoside analoguesJ Balzarini, S Velazquez, A San-Felix, et al.Molecular Pharmacology|May 1, 1996
Marked inhibitory activity of non-nucleoside reverse transcriptase inhibitors against human immunodeficiency virus type 1 when combined with (-)2',3'-dideoxy-3'-thiacytidineJ Balzarini, H Pelemans, M J Pérez-Pérez, et al.Biochemical Pharmacology|April 25, 2009
Identification of aspartic acid-203 in human thymidine phosphorylase as an important residue for both catalysis and non-competitive inhibition by the small molecule "crystallization chaperone" 5'-O-tritylinosine (KIN59)A Bronckaers, L Aguado, A Negri, et al.Nucleosides, Nucleotides & Nucleic Acids|October 21, 2003
Towards new thymidine phosphorylase/PD-ECGF inhibitors based on the transition state of the enzyme reactionE M Priego, J Mendieta, F Gago, et al.Pageof 6