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Biochemical Pharmacology|July 6, 1993
Metabolism and pharmacokinetics of the anti-HIV-1-specific inhibitor [1-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3-N- methyl-thymine]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dio xide)J Balzarini, L Naesens, C Bohman, et al.The Journal of Biological Chemistry|October 14, 1994
Resistance of HIV-1 reverse transcriptase against [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2''-dioxide)] (TSAO) derivatives is determined by the mutation Glu138-->Lys on the p51 subunitH Jonckheere, J M Taymans, J Balzarini, et al.Proceedings of the National Academy of Sciences of the United States of America|June 6, 1995
Suppression of the breakthrough of human immunodeficiency virus type 1 (HIV-1) in cell culture by thiocarboxanilide derivatives when used individually or in combination with other HIV-1-specific inhibitors (i.e., TSAO derivatives)J Balzarini, M J Pérez-Pérez, S Vélazquez, et al.Journal of Medicinal Chemistry|August 1, 1989
Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosidesM J Camarasa, A Diaz-Ortiz, A Calvo-Mateo, et al.Bioorganic & Medicinal Chemistry Letters|November 21, 2001
Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptaseC Chamorro, E Lobatón, M C Bonache, et al.Nucleosides, Nucleotides & Nucleic Acids|October 27, 2006
Thymidine phosphorylase is noncompetitively inhibited by 5'-O-trityl-inosine (KIN59) and related compoundsS Liekens, J Balzarini, A I Hernández, et al.The Journal of Biological Chemistry|June 15, 1992
Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5 "- (4"-amino-1",2"-oxathiole-2",2"-dioxide)thymine (TSAO-T)J Balzarini, M J Pérez-Pérez, A San-Félix, et al.FEBS Letters|November 20, 1998
7-Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylaseJ Balzarini, A E Gamboa, R Esnouf, et al.FEBS Letters|October 24, 2000
Kinetic analysis of novel multisubstrate analogue inhibitors of thymidine phosphorylaseJ Balzarini, B Degrève, A Esteban-Gamboa, et al.Nucleosides, Nucleotides & Nucleic Acids|September 21, 2001
"Second generation" of TSAO compounds directed against HIV-1 TSAO-resistant strainsE Lobatón, S Velázquez, M J Pérez-Pérez, et al.Pageof 6