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Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|
January 23, 2023
Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models
Gonzalo Rodriguez-Berriguete, Marco Ranzani, Remko Prevo, et al.
Science Advances
|
June 12, 2026
<i>SHLD2</i> loss is a synthetic vulnerability to Polθ inhibition combined with radiotherapy
Gonzalo Rodriguez-Berriguete, Purusotha Thambiayah, Alessandro Cicconi, et al.
Nucleic Acids Research
|
December 8, 2025
Mechanistic insights into the monotherapy and combination potential of FEN1 inhibition in cancer therapy
Eeson Rajendra, Claudio A Lademann, Bethany Mason, et al.
Journal of Medicinal Chemistry
|
December 8, 2025
Discovery of ART5537: A Potent and Selective Small-Molecule Probe for EXO1
Sam E Mann, Owen A Davis, Jörg Bomke, et al.
Journal of Medicinal Chemistry
|
October 6, 2022
Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta
Martin L Stockley, Amanda Ferdinand, Giovanni Benedetti, et al.
Journal of Medicinal Chemistry
|
December 4, 2024
Discovery of ART0380, a Potent and Selective ATR Kinase Inhibitor Undergoing Phase 2 Clinical Studies for the Treatment of Advanced or Metastatic Solid Cancers
Christopher L Carroll, Michael G Johnson, Yanbing Ding, et al.
Journal of Medicinal Chemistry
|
February 23, 2023
Correction to "Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta"
Martin L Stockley, Giovanni Benedetti, Peter Blencowe, et al.
Journal of Medicinal Chemistry
|
September 17, 2025
Fragment-Based Discovery and Structure-Led Optimization of MSC778, the First Potent, Selective, and Orally Bioavailable FEN1 Inhibitor
Sam E Mann, Julien Lefranc, Omar Alkhatib, et al.
Nature Communications
|
June 18, 2021
Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance
Diana Zatreanu, Helen M R Robinson, Omar Alkhatib, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|
February 28, 2024
Ataxia-Telangiectasia Mutated Loss-of-Function Displays Variant and Tissue-Specific Differences across Tumor Types
Patrick G Pilié, Virginia Giuliani, Wei-Lien Wang, et al.
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Showing results (131-140 of 140) with videos related to
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Page
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This site can display upto 140 results.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|
January 23, 2023
Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models
Gonzalo Rodriguez-Berriguete, Marco Ranzani, Remko Prevo, et al.
Science Advances
|
June 12, 2026
<i>SHLD2</i> loss is a synthetic vulnerability to Polθ inhibition combined with radiotherapy
Gonzalo Rodriguez-Berriguete, Purusotha Thambiayah, Alessandro Cicconi, et al.
Nucleic Acids Research
|
December 8, 2025
Mechanistic insights into the monotherapy and combination potential of FEN1 inhibition in cancer therapy
Eeson Rajendra, Claudio A Lademann, Bethany Mason, et al.
Journal of Medicinal Chemistry
|
December 8, 2025
Discovery of ART5537: A Potent and Selective Small-Molecule Probe for EXO1
Sam E Mann, Owen A Davis, Jörg Bomke, et al.
Journal of Medicinal Chemistry
|
October 6, 2022
Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta
Martin L Stockley, Amanda Ferdinand, Giovanni Benedetti, et al.
Journal of Medicinal Chemistry
|
December 4, 2024
Discovery of ART0380, a Potent and Selective ATR Kinase Inhibitor Undergoing Phase 2 Clinical Studies for the Treatment of Advanced or Metastatic Solid Cancers
Christopher L Carroll, Michael G Johnson, Yanbing Ding, et al.
Journal of Medicinal Chemistry
|
February 23, 2023
Correction to "Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta"
Martin L Stockley, Giovanni Benedetti, Peter Blencowe, et al.
Journal of Medicinal Chemistry
|
September 17, 2025
Fragment-Based Discovery and Structure-Led Optimization of MSC778, the First Potent, Selective, and Orally Bioavailable FEN1 Inhibitor
Sam E Mann, Julien Lefranc, Omar Alkhatib, et al.
Nature Communications
|
June 18, 2021
Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance
Diana Zatreanu, Helen M R Robinson, Omar Alkhatib, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|
February 28, 2024
Ataxia-Telangiectasia Mutated Loss-of-Function Displays Variant and Tissue-Specific Differences across Tumor Types
Patrick G Pilié, Virginia Giuliani, Wei-Lien Wang, et al.
Page
of 14