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The Journal of Biological Chemistry|March 6, 2025
Covalent inhibition of the SARS-CoV-2 NiRAN domain via an active-site cysteineGenaro Hernandez, Adam Osinski, Abir Majumdar, et al.
Antiviral Research|August 26, 2018
Inhibiting pyrimidine biosynthesis impairs Ebola virus replication through depletion of nucleoside pools and activation of innate immune responsesPriya Luthra, Jacinth Naidoo, Colette A Pietzsch, et al.
Journal of Medicinal Chemistry|August 14, 2020
Tumor-Activated Benzothiazole Inhibitors of Stearoyl-CoA DesaturaseNoelle S Williams, Stephen Gonzales, Jacinth Naidoo, et al.
JCI Insight|February 18, 2021
15-PGDH inhibition activates the splenic niche to promote hematopoietic regenerationJulianne Np Smith, Dawn M Dawson, Kelsey F Christo, et al.
ACS Chemical Biology|June 3, 2024
Thiophenyl Derivatives of Nicotinamide Are Metabolized by the NAD Salvage Pathway into Unnatural NAD Derivatives That Inhibit IMPDH and Are Toxic to Peripheral Nerve CancersPanayotis C Theodoropoulos, Holly H Guo, Wentian Wang, et al.
Journal of Medicinal Chemistry|November 2, 2022
Orally Bioavailable Quinoxaline Inhibitors of 15-Prostaglandin Dehydrogenase (15-PGDH) Promote Tissue Repair and RegenerationBin Hu, Kosuke Toda, Xiaoyu Wang, et al.
Nature Communications|July 20, 2024
Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiencyRachel Tesla, Charlotte Guhl, Gordon C Werthmann, et al.
NPJ Parkinson'S Disease|May 10, 2016
Protective efficacy of P7C3-S243 in the 6-hydroxydopamine model of Parkinson's diseaseHéctor De Jesús-Cortés, Adam D Miller, Jeremiah K Britt, et al.
Journal of the American Chemical Society|January 8, 2011
Development of proneurogenic, neuroprotective small moleculesKaren S MacMillan, Jacinth Naidoo, Jue Liang, et al.
Proceedings of the National Academy of Sciences of the United States of America|October 3, 2012
Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosisRachel Tesla, Hamilton Parker Wolf, Pin Xu, et al.
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