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Biological Psychiatry
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November 13, 2012
Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity
Jerri M Rook, Meredith J Noetzel, Wendy A Pouliot, et al.
ACS Medicinal Chemistry Letters
|
August 20, 2021
Discovery of VU6028418: A Highly Selective and Orally Bioavailable M<sub>4</sub> Muscarinic Acetylcholine Receptor Antagonist
Matthew Spock, Trever R Carter, Katrina A Bollinger, et al.
ACS Chemical Neuroscience
|
August 28, 2024
Discovery of VU6007496: Challenges in the Development of an M<sub>1</sub> Positive Allosteric Modulator Backup Candidate
Julie L Engers, Katrina A Bollinger, Rory A Capstick, et al.
ACS Chemical Neuroscience
|
March 25, 2025
Application of Deuterium in an M<sub>1</sub> Positive Allosteric Modulator Back-Up Program: The Discovery of VU6045422
Julie L Engers, Jinming Li, Changho Han, et al.
Molecular Pharmacology
|
October 7, 2010
Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity
Alice L Rodriguez, Mark D Grier, Carrie K Jones, et al.
ACS Chemical Neuroscience
|
February 5, 2025
Further Optimization of the mGlu<sub>1</sub> PAM VU6024578/BI02982816: Discovery and Characterization of VU6033685
Carson W Reed, Jacob F Kalbfleisch, Jeremy A Turkett, et al.
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|
August 29, 2015
Partial mGlu₅ Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like Effects
Robert W Gould, Russell J Amato, Michael Bubser, et al.
Journal of Medicinal Chemistry
|
May 23, 2017
Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation
Andrew S Felts, Alice L Rodriguez, Anna L Blobaum, et al.
ACS Chemical Neuroscience
|
November 26, 2025
Discovery of VU6052254: A Novel, Potent M<sub>1</sub> Positive Allosteric Modulator
Julie L Engers, Joseph D Bungard, Christopher C Presley, et al.
Bioorganic & Medicinal Chemistry Letters
|
October 18, 2015
Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators
Chrysa Malosh, Mark Turlington, Thomas M Bridges, et al.
Page
of 11
Search research articles
Search
Showing results (91-100 of 110) with videos related to
Sort By:
Page
of 11
Biological Psychiatry
|
November 13, 2012
Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity
Jerri M Rook, Meredith J Noetzel, Wendy A Pouliot, et al.
ACS Medicinal Chemistry Letters
|
August 20, 2021
Discovery of VU6028418: A Highly Selective and Orally Bioavailable M<sub>4</sub> Muscarinic Acetylcholine Receptor Antagonist
Matthew Spock, Trever R Carter, Katrina A Bollinger, et al.
ACS Chemical Neuroscience
|
August 28, 2024
Discovery of VU6007496: Challenges in the Development of an M<sub>1</sub> Positive Allosteric Modulator Backup Candidate
Julie L Engers, Katrina A Bollinger, Rory A Capstick, et al.
ACS Chemical Neuroscience
|
March 25, 2025
Application of Deuterium in an M<sub>1</sub> Positive Allosteric Modulator Back-Up Program: The Discovery of VU6045422
Julie L Engers, Jinming Li, Changho Han, et al.
Molecular Pharmacology
|
October 7, 2010
Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity
Alice L Rodriguez, Mark D Grier, Carrie K Jones, et al.
ACS Chemical Neuroscience
|
February 5, 2025
Further Optimization of the mGlu<sub>1</sub> PAM VU6024578/BI02982816: Discovery and Characterization of VU6033685
Carson W Reed, Jacob F Kalbfleisch, Jeremy A Turkett, et al.
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|
August 29, 2015
Partial mGlu₅ Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like Effects
Robert W Gould, Russell J Amato, Michael Bubser, et al.
Journal of Medicinal Chemistry
|
May 23, 2017
Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation
Andrew S Felts, Alice L Rodriguez, Anna L Blobaum, et al.
ACS Chemical Neuroscience
|
November 26, 2025
Discovery of VU6052254: A Novel, Potent M<sub>1</sub> Positive Allosteric Modulator
Julie L Engers, Joseph D Bungard, Christopher C Presley, et al.
Bioorganic & Medicinal Chemistry Letters
|
October 18, 2015
Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators
Chrysa Malosh, Mark Turlington, Thomas M Bridges, et al.
Page
of 11