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ACS Chemical Neuroscience
|
January 26, 2026
Discovery of 7-(Pyridin-3-yl)thieno[3,2-<i>b</i>]pyridine-5-carboxamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5
Scott H Henderson, Anna E Ringuette, David L Whomble, et al.
ACS Pharmacology & Translational Science
|
August 23, 2021
Discovery of the First Selective M<sub>4</sub> Muscarinic Acetylcholine Receptor Antagonists with <i>in Vivo</i> Antiparkinsonian and Antidystonic Efficacy
Mark S Moehle, Aaron M Bender, Jonathan W Dickerson, et al.
ACS Medicinal Chemistry Letters
|
December 18, 2024
Discovery of 4-(5-Membered)Heteroarylether-6-methylpicolinamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5
Elizabeth S Childress, Rory A Capstick, Katherine E Crocker, et al.
Journal of Medicinal Chemistry
|
December 12, 2024
Discovery of VU6024578/BI02982816: An mGlu<sub>1</sub> Positive Allosteric Modulator with Efficacy in Preclinical Antipsychotic and Cognition Models
Carson W Reed, Jacob F Kalbfleisch, Jeremy A Turkett, et al.
ACS Medicinal Chemistry Letters
|
July 10, 2015
Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia
Susana Conde-Ceide, Carlos M Martínez-Viturro, Jesús Alcázar, et al.
Journal of Medicinal Chemistry
|
October 17, 2025
Optimization of Selective and CNS Penetrant Alkyne-Based TREK Inhibitors: The Discovery and Characterization of ONO-9517601 (VU6022856) and ONO-7927846 (VU6024391)
Motoyuki Tanaka, Yoko Sekioka, Gakuji Hashimoto, et al.
ACS Medicinal Chemistry Letters
|
May 14, 2025
Discovery of Thieno[3,2-<i>b</i>]pyridine-5-carboxamide and 2,3-Difluorobenzamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5
Katherine E Crocker, Scott H Henderson, Rory A Capstick, et al.
ACS Chemical Neuroscience
|
January 25, 2026
Discovery of VU6025733 (AG06827): A Highly Selective, Orally Bioavailable, and Structurally Distinct M<sub>4</sub> Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust <i>In Vivo</i> Efficacy
Alison R Gregro, Charlotte Park, Madeline F Long, et al.
ACS Chemical Neuroscience
|
December 11, 2024
Discovery of VU0467319: an M<sub>1</sub> Positive Allosteric Modulator Candidate That Advanced into Clinical Trials
Michael S Poslunsey, Michael R Wood, Changho Han, et al.
Neuron
|
May 5, 2015
Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents
Jerri M Rook, Zixiu Xiang, Xiaohui Lv, et al.
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Search research articles
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Showing results (101-110 of 110) with videos related to
Sort By:
Page
of 11
You have reached the last page of results.
This site can display upto 110 results.
ACS Chemical Neuroscience
|
January 26, 2026
Discovery of 7-(Pyridin-3-yl)thieno[3,2-<i>b</i>]pyridine-5-carboxamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5
Scott H Henderson, Anna E Ringuette, David L Whomble, et al.
ACS Pharmacology & Translational Science
|
August 23, 2021
Discovery of the First Selective M<sub>4</sub> Muscarinic Acetylcholine Receptor Antagonists with <i>in Vivo</i> Antiparkinsonian and Antidystonic Efficacy
Mark S Moehle, Aaron M Bender, Jonathan W Dickerson, et al.
ACS Medicinal Chemistry Letters
|
December 18, 2024
Discovery of 4-(5-Membered)Heteroarylether-6-methylpicolinamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5
Elizabeth S Childress, Rory A Capstick, Katherine E Crocker, et al.
Journal of Medicinal Chemistry
|
December 12, 2024
Discovery of VU6024578/BI02982816: An mGlu<sub>1</sub> Positive Allosteric Modulator with Efficacy in Preclinical Antipsychotic and Cognition Models
Carson W Reed, Jacob F Kalbfleisch, Jeremy A Turkett, et al.
ACS Medicinal Chemistry Letters
|
July 10, 2015
Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia
Susana Conde-Ceide, Carlos M Martínez-Viturro, Jesús Alcázar, et al.
Journal of Medicinal Chemistry
|
October 17, 2025
Optimization of Selective and CNS Penetrant Alkyne-Based TREK Inhibitors: The Discovery and Characterization of ONO-9517601 (VU6022856) and ONO-7927846 (VU6024391)
Motoyuki Tanaka, Yoko Sekioka, Gakuji Hashimoto, et al.
ACS Medicinal Chemistry Letters
|
May 14, 2025
Discovery of Thieno[3,2-<i>b</i>]pyridine-5-carboxamide and 2,3-Difluorobenzamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5
Katherine E Crocker, Scott H Henderson, Rory A Capstick, et al.
ACS Chemical Neuroscience
|
January 25, 2026
Discovery of VU6025733 (AG06827): A Highly Selective, Orally Bioavailable, and Structurally Distinct M<sub>4</sub> Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust <i>In Vivo</i> Efficacy
Alison R Gregro, Charlotte Park, Madeline F Long, et al.
ACS Chemical Neuroscience
|
December 11, 2024
Discovery of VU0467319: an M<sub>1</sub> Positive Allosteric Modulator Candidate That Advanced into Clinical Trials
Michael S Poslunsey, Michael R Wood, Changho Han, et al.
Neuron
|
May 5, 2015
Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents
Jerri M Rook, Zixiu Xiang, Xiaohui Lv, et al.
Page
of 11