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Bioorganic & Medicinal Chemistry Letters
|
July 2, 2019
Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as RORγt inverse agonists
Zhonghui Lu, James J-W Duan, Haiyun Xiao, et al.
ACS Medicinal Chemistry Letters
|
March 21, 2019
Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists
James J-W Duan, Zhonghui Lu, Bin Jiang, et al.
Bioorganic & Medicinal Chemistry Letters
|
May 26, 2017
Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors
John Hynes, Hong Wu, James Kempson, et al.
Experimental Dermatology
|
April 2, 2015
Evidence that a neutrophil-keratinocyte crosstalk is an early target of IL-17A inhibition in psoriasis
Kristian Reich, Kim A Papp, Robert T Matheson, et al.
ACS Medicinal Chemistry Letters
|
March 21, 2019
Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis
Steven H Spergel, Michael E Mertzman, James Kempson, et al.
Bioorganic & Medicinal Chemistry Letters
|
December 3, 2014
Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors
James J-W Duan, Zhonghui Lu, Bin Jiang, et al.
JHEP Reports : Innovation in Hepatology
|
July 24, 2023
Identification and characterisation of a rare <i>MTTP</i> variant underlying hereditary non-alcoholic fatty liver disease
Jane I Grove, Peggy C K Lo, Nick Shrine, et al.
Science Translational Medicine
|
July 26, 2019
Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain
James R Burke, Lihong Cheng, Kathleen M Gillooly, et al.
The European Respiratory Journal
|
July 26, 2024
Benralizumab for allergic asthma: a randomised, double-blind, placebo-controlled trial
Gail M Gauvreau, Roma Sehmi, J Mark FitzGerald, et al.
Bioorganic & Medicinal Chemistry Letters
|
December 14, 2017
Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity
Hua Gong, David S Weinstein, Zhonghui Lu, et al.
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Search research articles
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Showing results (381-390 of 393) with videos related to
Sort By:
Page
of 40
Bioorganic & Medicinal Chemistry Letters
|
July 2, 2019
Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as RORγt inverse agonists
Zhonghui Lu, James J-W Duan, Haiyun Xiao, et al.
ACS Medicinal Chemistry Letters
|
March 21, 2019
Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists
James J-W Duan, Zhonghui Lu, Bin Jiang, et al.
Bioorganic & Medicinal Chemistry Letters
|
May 26, 2017
Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors
John Hynes, Hong Wu, James Kempson, et al.
Experimental Dermatology
|
April 2, 2015
Evidence that a neutrophil-keratinocyte crosstalk is an early target of IL-17A inhibition in psoriasis
Kristian Reich, Kim A Papp, Robert T Matheson, et al.
ACS Medicinal Chemistry Letters
|
March 21, 2019
Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis
Steven H Spergel, Michael E Mertzman, James Kempson, et al.
Bioorganic & Medicinal Chemistry Letters
|
December 3, 2014
Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors
James J-W Duan, Zhonghui Lu, Bin Jiang, et al.
JHEP Reports : Innovation in Hepatology
|
July 24, 2023
Identification and characterisation of a rare <i>MTTP</i> variant underlying hereditary non-alcoholic fatty liver disease
Jane I Grove, Peggy C K Lo, Nick Shrine, et al.
Science Translational Medicine
|
July 26, 2019
Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain
James R Burke, Lihong Cheng, Kathleen M Gillooly, et al.
The European Respiratory Journal
|
July 26, 2024
Benralizumab for allergic asthma: a randomised, double-blind, placebo-controlled trial
Gail M Gauvreau, Roma Sehmi, J Mark FitzGerald, et al.
Bioorganic & Medicinal Chemistry Letters
|
December 14, 2017
Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity
Hua Gong, David S Weinstein, Zhonghui Lu, et al.
Page
of 40