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Molecular Cell|October 7, 2020
Differential GLP-1R Binding and Activation by Peptide and Non-peptide AgonistsXin Zhang, Matthew J Belousoff, Peishen Zhao, et al.
BMJ Open Diabetes Research & Care|November 16, 2021
Deletion of GPR21 improves glucose homeostasis and inhibits the CCL2-CCR2 axis by divergent mechanismsDarren M Riddy, Helene L Kammoun, Andrew J Murphy, et al.
ACS Pharmacology & Translational Science|March 15, 2019
DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs in Vitro and in VivoKaren J Thompson, Elham Khajehali, Sophie J Bradley, et al.
ACS Chemical Neuroscience|April 22, 2018
Discovery and Optimization of Potent and CNS Penetrant M5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide ScaffoldAaron M Bender, Hyekyung P Cho, Kellie D Nance, et al.
Science Advances|February 4, 2026
In vivo functional profiling and structural characterization of the human GLP1R A316T variantLiliane El Eid, Yusman Manchanda, Gregory Austin, et al.
The Journal of Clinical Investigation|December 20, 2016
M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory lossSophie J Bradley, Julie-Myrtille Bourgognon, Helen E Sanger, et al.
Nature Chemical Biology|February 22, 2020
Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugsSophie J Bradley, Colin Molloy, Paulina Valuskova, et al.
Nature|September 9, 2021
Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesiaChristopher J Draper-Joyce, Rebecca Bhola, Jinan Wang, et al.
Biorxiv : the Preprint Server for Biology|June 12, 2025
De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptorsEdin Muratspahić, David Feldman, David E Kim, et al.
Cell|November 25, 2021
From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's diseaseAlastair J H Brown, Sophie J Bradley, Fiona H Marshall, et al.
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