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Frontiers in Physiology|December 19, 2012
Modeling drug- and chemical-induced hepatotoxicity with systems biology approachesSudin Bhattacharya, Lisl K M Shoda, Qiang Zhang, et al.
Toxicological Sciences : an Official Journal of the Society of Toxicology|May 7, 2026
RENAsym, a Quantitative Systems Toxicology Platform Model, Designed to Predict Drug-Induced Kidney Injury Indicates Polymyxin B and Valproate Overdose Toxicity Potential While Simultaneously Demonstrating Acetaminophen and Valproate Safety at Therapeutic LevelsCeleste Vallejo, Pallavi Bhargava, Nader Hamzavi, et al.
Clinical Pharmacology and Therapeutics|January 16, 2026
Quantitative Systems Toxicology Modeling with DILIsym to Support Phase 3 Dose Selection for FezolinetantJace C Nielsen, Jeffrey L Woodhead, Brett A Howell, et al.
Pharmacology Research & Perspectives|October 19, 2019
Quantitative systems toxicology (QST) reproduces species differences in PF-04895162 liver safety due to combined mitochondrial and bile acid toxicityGrant Generaux, Vinal V Lakhani, Yuching Yang, et al.
Immunity|August 23, 2005
A comprehensive review of interventions in the NOD mouse and implications for translationLisl K M Shoda, Daniel L Young, Saroja Ramanujan, et al.
Toxicological Sciences : an Official Journal of the Society of Toxicology|September 23, 2016
Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility FactorsJeffrey L Woodhead, William J Brock, Sharin E Roth, et al.
International Journal of Molecular Sciences|June 10, 2023
The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver InjuryJames J Beaudoin, Lara Clemens, Mark T Miedel, et al.
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