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Current Oncology (Toronto, Ont.)|August 13, 2009
Postoperative extended-volume external-beam radiation therapy in high-risk esophageal cancer patients: a prospective experienceE Yu, P Tai, J Younus, et al.Cancer|January 29, 2000
Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumorsN D Doolittle, M E Miner, W A Hall, et al.Journal of Medicinal Chemistry|January 21, 2012
[1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket bindingMichael D Shultz, Christina A Kirby, Travis Stams, et al.Chemistry & Biology|December 30, 2014
The novolactone natural product disrupts the allosteric regulation of Hsp70A Quamrul Hassan, Christina A Kirby, Wenlai Zhou, et al.ACS Medicinal Chemistry Letters|February 16, 2017
Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1Julian R Levell, Thomas Caferro, Gregg Chenail, et al.Journal of Medicinal Chemistry|July 13, 2013
Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitorMichael D Shultz, Atwood K Cheung, Christina A Kirby, et al.Journal of Medicinal Chemistry|June 28, 2016
Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase InhibitorJorge Garcia Fortanet, Christine Hiu-Tung Chen, Ying-Nan P Chen, et al.Cancer Discovery|November 2, 2023
Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from HyperinsulinemiaAndreas Varkaris, Ermira Pazolli, Hakan Gunaydin, et al.Nature|July 1, 2016
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinasesYing-Nan P Chen, Matthew J LaMarche, Ho Man Chan, et al.Journal of Medicinal Chemistry|September 10, 2020
Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of CancerMatthew J LaMarche, Michael Acker, Andreea Argintaru, et al.Pageof 33