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Bioorganic & Medicinal Chemistry Letters|November 13, 2013
Metabolism-guided discovery of a potent and orally bioavailable urea-based calcimimetic for the treatment of secondary hyperparathyroidismPaul M Wehn, Paul E Harrington, Timothy J Carlson, et al.Cancer Research|September 17, 2016
A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell CarcinomaEli M Wallace, James P Rizzi, Guangzhou Han, et al.Journal of Medicinal Chemistry|October 6, 2018
Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate ( S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1 H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385)Paul M Wehn, James P Rizzi, Darryl D Dixon, et al.Science (New York, N.Y.)|June 12, 2025
BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interactionDhirendra K Simanshu, Rui Xu, James P Stice, et al.Journal of Medicinal Chemistry|March 20, 2014
Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3Zhihong Li, Xianghong Wang, John Eksterowicz, et al.Pageof 2