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Biorxiv : the Preprint Server for Biology|August 2, 2024
Ribosomal Frameshifting Selectively Modulates the Assembly, Function, and Pharmacological Rescue of a Misfolded CFTR VariantPatrick Carmody, Francis J Roushar, Austin Tedman, et al.
Elife|July 21, 2016
Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregationLars Plate, Christina B Cooley, John J Chen, et al.
Biorxiv : the Preprint Server for Biology|June 12, 2026
Profiling the CFTR Variant Selectivity and Off-Target Interactions of VX-121Ashish Rajesh Jhangiani, John A Olson, Austin Tedman, et al.
Proceedings of the National Academy of Sciences of the United States of America|October 10, 2024
Ribosomal frameshifting selectively modulates the assembly, function, and pharmacological rescue of a misfolded CFTR variantPatrick J Carmody, Francis J Roushar, Austin Tedman, et al.
Molecular Therapy : the Journal of the American Society of Gene Therapy|February 5, 2021
Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegenerationRené L Vidal, Denisse Sepulveda, Paulina Troncoso-Escudero, et al.
Hepatology (Baltimore, Md.)|April 9, 2025
Targeting the ER stress sensor IRE1 protects the liver from fibrosis through the downregulation of the proteostasis factor P4HB/PDIA1Younis Hazari, Lama Habbouche, Valeria A Garcia Lopez, et al.
Biorxiv : the Preprint Server for Biology|May 19, 2023
The endoplasmic reticulum stress sensor IRE1 regulates collagen secretion through the enforcement of the proteostasis factor P4HB/PDIA1 contributing to liver damage and fibrosisYounis Hazari, Hery Urra, Valeria A Garcia Lopez, et al.
Acta Neuropathologica|July 10, 2020
Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregatesPaula García-Huerta, Paulina Troncoso-Escudero, Di Wu, et al.
Molecular Therapy : the Journal of the American Society of Gene Therapy|April 5, 2023
The unfolded protein response transcription factor XBP1s ameliorates Alzheimer's disease by improving synaptic function and proteostasisClaudia Duran-Aniotz, Natalia Poblete, Catalina Rivera-Krstulovic, et al.
The EMBO Journal|October 31, 2022
Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain agingFelipe Cabral-Miranda, Giovanni Tamburini, Gabriela Martinez, et al.
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