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FEBS Letters|May 14, 2005
Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-proteinToru Sato, Yu Tanimura, Naoko Hirotani, et al.
Biochemistry|October 20, 2004
Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42Satoru Funamoto, Maho Morishima-Kawashima, Yu Tanimura, et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience|October 16, 2009
gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragmentMako Takami, Yu Nagashima, Yoshihisa Sano, et al.
Biochemistry|November 26, 2003
Gamma-secretase activity is present in rafts but is not cholesterol-dependentSatoko Wada, Maho Morishima-Kawashima, Yue Qi, et al.
Acta Neuropathologica Communications|December 31, 2025
Coordinated regional association of cathepsins and dipeptidyl peptidases with N-truncated Abeta42, Abeta40, and tau in Alzheimer's brainMitsuru Shinohara, Ghupurjan Gheni, Kaori Kawai, et al.
Scientific Reports|March 1, 2020
Neuron-specific analysis of histone modifications with post-mortem brainsKagari Koshi-Mano, Tatsuo Mano, Maho Morishima, et al.
Human Molecular Genetics|December 17, 2019
Enhanced amyloid-β generation by γ-secretase complex in DRM microdomains with reduced cholesterol levelsSaori Hata, Anqi Hu, Yi Piao, et al.
The Journal of Biological Chemistry|December 31, 2013
γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragmentNobutaka Matsumura, Mako Takami, Masayasu Okochi, et al.
The Journal of Biological Chemistry|April 24, 2008
Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment betaMasafumi Shimojo, Naruhiko Sahara, Tatsuya Mizoroki, et al.
Cell Reports|September 3, 2025
Biomarker-related phospho-tau217 appears in synapses around Aβ plaques prior to tau tangle in cerebral cortex of preclinical Alzheimer's diseaseYu Hirota, Yasufumi Sakakibara, Maho Morishima, et al.
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