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Journal of Medicinal Chemistry|January 6, 2021
Discovery of a Novel and Brain-Penetrant O-GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead OptimizationMichiko Tawada, Makoto Fushimi, Kei Masuda, et al.Journal of the American Chemical Society|April 20, 2023
Regiodivergent Nucleophilic Fluorination under Hydrogen Bonding Catalysis: A Computational and Experimental StudyMatthew A Horwitz, Alexander B Dürr, Konstantinos Afratis, et al.Patterns (New York, N.Y.)|December 18, 2020
Prediction of Compound Bioactivities Using Heat-Diffusion EquationTadashi Hidaka, Keiko Imamura, Takeshi Hioki, et al.Journal of Medicinal Chemistry|November 11, 2014
Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitorJun Kunitomo, Masato Yoshikawa, Makoto Fushimi, et al.Molecular Human Reproduction|August 31, 2021
Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilizationMelanie Balbach, Lubna Ghanem, Thomas Rossetti, et al.Journal of Chemical Information and Modeling|April 15, 2023
Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy PerturbationShan Sun, Makoto Fushimi, Thomas Rossetti, et al.Journal of Medicinal Chemistry|April 23, 2019
Discovery of Potent, Selective, and Brain-Penetrant 1 H-Pyrazol-5-yl-1 H-pyrrolo[2,3- b]pyridines as Anaplastic Lymphoma Kinase (ALK) InhibitorsMakoto Fushimi, Ikuo Fujimori, Takeshi Wakabayashi, et al.Journal of Medicinal Chemistry|November 8, 2022
Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation RatesMichael Miller, Thomas Rossetti, Jacob Ferreira, et al.ACS Medicinal Chemistry Letters|August 20, 2021
Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10)Makoto Fushimi, Hannes Buck, Melanie Balbach, et al.Journal of Medicinal Chemistry|October 21, 2025
Discovery of Pyrazole-Based Positron Emission Tomography Agent that Maps Histone Deacetylase 6 (HDAC6) in the Nonhuman Primate BrainTomoteru Yamasaki, Norio Ohyabu, Takeshi Wakabayashi, et al.Pageof 2