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Bioorganic & Medicinal Chemistry|October 3, 2018
A novel 2,4-diaminopyrimidine derivative as selective inhibitor of protein kinase C theta prevents allograft rejection in a rat heart transplant modelShigeki Kunikawa, Akira Tanaka, Yuji Takasuna, et al.
Bioorganic & Medicinal Chemistry|February 2, 2019
Discovery of 2,4-diamino-5-cyanopyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug-drug interactionsShigeki Kunikawa, Akira Tanaka, Yuji Takasuna, et al.
Cancer Immunology, Immunotherapy : CII|April 28, 2021
IL-7 coupled with IL-12 increases intratumoral T cell clonality, leading to complete regression of non-immunogenic tumorsMamoru Tasaki, Midori Yamashita, Yukinori Arai, et al.
Molecular Therapy Oncolytics|March 5, 2021
Oncolytic vaccinia virus induces a novel phenotype of CD8+ effector T cells characterized by high ICOS expressionMidori Yamashita, Mamoru Tasaki, Ryuji Murakami, et al.
Bioorganic & Medicinal Chemistry|May 19, 2015
Optimization of 2,4-diamino-5-fluoropyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug-drug interactions and P-gp liabilityShigeki Kunikawa, Akira Tanaka, Koichiro Mukoyoshi, et al.
Journal of Human Genetics|June 27, 2003
Leber's hereditary optic neuropathy with 14484 mutation in Central Java, IndonesiaTomoki Nishioka, Mamoru Tasaki, Augustinus Soemantri, et al.
European Journal of Pharmacology|December 3, 2014
Effect of AS2521780, a novel PKCθ selective inhibitor, on T cell-mediated immunityHidehiko Fukahori, Noboru Chida, Masashi Maeda, et al.
European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences|April 30, 2013
Inhibition of antigen-induced airway inflammation and hyperresponsiveness in guinea pigs by a selective antagonist of "chemoattractant receptor homologous molecule expressed on Th2 cells" (CRTH2)Mamoru Tasaki, Miki Kobayashi, Yoshiyuki Tenda, et al.
Science Translational Medicine|January 17, 2020
Intratumoral expression of IL-7 and IL-12 using an oncolytic virus increases systemic sensitivity to immune checkpoint blockadeShinsuke Nakao, Yukinori Arai, Mamoru Tasaki, et al.
International Immunopharmacology|July 1, 2015
Effect of novel PKCθ selective inhibitor AS2521780 on acute rejection in rat and non-human primate models of transplantationHidehiko Fukahori, Noboru Chida, Masashi Maeda, et al.
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