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Journal of Medicinal Chemistry
|
November 8, 2017
Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate
Stefano Crosignani, Patrick Bingham, Pauline Bottemanne, et al.
Molecular Cancer Therapeutics
|
September 21, 2018
Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy
Bruno Gomes, Gregory Driessens, Derek Bartlett, et al.
The Journal of Biological Chemistry
|
December 2, 2010
Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor
Kumiko Nagashima, Stuart D Shumway, Sriram Sathyanarayanan, et al.
Cancer Research
|
April 16, 2011
PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models
Katharine Ellwood-Yen, Heike Keilhack, Kaiko Kunii, et al.
Plos One
|
May 25, 2012
Efficacious intermittent dosing of a novel JAK2 inhibitor in mouse models of polycythemia vera
Manfred Kraus, Yuxun Wang, Dan Aleksandrowicz, et al.
Journal of Medicinal Chemistry
|
December 7, 2017
Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497)
Pei-Pei Kung, Patrick Bingham, Alexei Brooun, et al.
Journal of Medicinal Chemistry
|
March 20, 2023
Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1
Rebecca A Gallego, Louise Bernier, Hui Chen, et al.
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Showing results (21-30 of 27) with videos related to
Sort By:
Page
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You have reached the last page of results.
This site can display upto 27 results.
Journal of Medicinal Chemistry
|
November 8, 2017
Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate
Stefano Crosignani, Patrick Bingham, Pauline Bottemanne, et al.
Molecular Cancer Therapeutics
|
September 21, 2018
Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy
Bruno Gomes, Gregory Driessens, Derek Bartlett, et al.
The Journal of Biological Chemistry
|
December 2, 2010
Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor
Kumiko Nagashima, Stuart D Shumway, Sriram Sathyanarayanan, et al.
Cancer Research
|
April 16, 2011
PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models
Katharine Ellwood-Yen, Heike Keilhack, Kaiko Kunii, et al.
Plos One
|
May 25, 2012
Efficacious intermittent dosing of a novel JAK2 inhibitor in mouse models of polycythemia vera
Manfred Kraus, Yuxun Wang, Dan Aleksandrowicz, et al.
Journal of Medicinal Chemistry
|
December 7, 2017
Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497)
Pei-Pei Kung, Patrick Bingham, Alexei Brooun, et al.
Journal of Medicinal Chemistry
|
March 20, 2023
Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1
Rebecca A Gallego, Louise Bernier, Hui Chen, et al.
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of 3